Energy constraints on brain network formation

Abstract Energy constraints are a fundamental limitation of the brain, which is physically embedded in a restricted space. The collective dynamics of neurons through connections enable the brain to achieve rich functionality, but building connections and maintaining activity come at a high cost. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Kosuke Takagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ff6ba7f76d646408e80a6a2cd20e7e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ff6ba7f76d646408e80a6a2cd20e7e4
record_format	dspace
spelling	oai:doaj.org-article:9ff6ba7f76d646408e80a6a2cd20e7e42021-12-02T17:50:49ZEnergy constraints on brain network formation10.1038/s41598-021-91250-y2045-2322https://doaj.org/article/9ff6ba7f76d646408e80a6a2cd20e7e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91250-yhttps://doaj.org/toc/2045-2322Abstract Energy constraints are a fundamental limitation of the brain, which is physically embedded in a restricted space. The collective dynamics of neurons through connections enable the brain to achieve rich functionality, but building connections and maintaining activity come at a high cost. The effects of reducing these costs can be found in the characteristic structures of the brain network. Nevertheless, the mechanism by which energy constraints affect the organization and formation of the neuronal network in the brain is unclear. Here, it is shown that a simple model based on cost minimization can reproduce structures characteristic of the brain network. With reference to the behavior of neurons in real brains, the cost function was introduced in an activity-dependent form correlating the activity cost and the wiring cost as a simple ratio. Cost reduction of this ratio resulted in strengthening connections, especially at highly activated nodes, and induced the formation of large clusters. Regarding these network features, statistical similarity was confirmed by comparison to connectome datasets from various real brains. The findings indicate that these networks share an efficient structure maintained with low costs, both for activity and for wiring. These results imply the crucial role of energy constraints in regulating the network activity and structure of the brain.Kosuke TakagiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kosuke Takagi Energy constraints on brain network formation
description	Abstract Energy constraints are a fundamental limitation of the brain, which is physically embedded in a restricted space. The collective dynamics of neurons through connections enable the brain to achieve rich functionality, but building connections and maintaining activity come at a high cost. The effects of reducing these costs can be found in the characteristic structures of the brain network. Nevertheless, the mechanism by which energy constraints affect the organization and formation of the neuronal network in the brain is unclear. Here, it is shown that a simple model based on cost minimization can reproduce structures characteristic of the brain network. With reference to the behavior of neurons in real brains, the cost function was introduced in an activity-dependent form correlating the activity cost and the wiring cost as a simple ratio. Cost reduction of this ratio resulted in strengthening connections, especially at highly activated nodes, and induced the formation of large clusters. Regarding these network features, statistical similarity was confirmed by comparison to connectome datasets from various real brains. The findings indicate that these networks share an efficient structure maintained with low costs, both for activity and for wiring. These results imply the crucial role of energy constraints in regulating the network activity and structure of the brain.
format	article
author	Kosuke Takagi
author_facet	Kosuke Takagi
author_sort	Kosuke Takagi
title	Energy constraints on brain network formation
title_short	Energy constraints on brain network formation
title_full	Energy constraints on brain network formation
title_fullStr	Energy constraints on brain network formation
title_full_unstemmed	Energy constraints on brain network formation
title_sort	energy constraints on brain network formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ff6ba7f76d646408e80a6a2cd20e7e4
work_keys_str_mv	AT kosuketakagi energyconstraintsonbrainnetworkformation
_version_	1718379302629670912

Energy constraints on brain network formation

Ejemplares similares