Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a H...

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Autores principales:	Agnieszka Czechowicz, Rahul Palchaudhuri, Amelia Scheck, Yu Hu, Jonathan Hoggatt, Borja Saez, Wendy W. Pang, Michael K. Mansour, Tiffany A. Tate, Yan Yi Chan, Emily Walck, Gerlinde Wernig, Judith A. Shizuru, Florian Winau, David T. Scadden, Derrick J. Rossi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ffac621975f4bccb6eaeafd10b5ba55
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spelling	oai:doaj.org-article:9ffac621975f4bccb6eaeafd10b5ba552021-12-02T15:35:28ZSelective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation10.1038/s41467-018-08201-x2041-1723https://doaj.org/article/9ffac621975f4bccb6eaeafd10b5ba552019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08201-xhttps://doaj.org/toc/2041-1723Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a HSC marker, allows specific and efficient preconditioning for HSC therapy.Agnieszka CzechowiczRahul PalchaudhuriAmelia ScheckYu HuJonathan HoggattBorja SaezWendy W. PangMichael K. MansourTiffany A. TateYan Yi ChanEmily WalckGerlinde WernigJudith A. ShizuruFlorian WinauDavid T. ScaddenDerrick J. RossiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agnieszka Czechowicz Rahul Palchaudhuri Amelia Scheck Yu Hu Jonathan Hoggatt Borja Saez Wendy W. Pang Michael K. Mansour Tiffany A. Tate Yan Yi Chan Emily Walck Gerlinde Wernig Judith A. Shizuru Florian Winau David T. Scadden Derrick J. Rossi Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
description	Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a HSC marker, allows specific and efficient preconditioning for HSC therapy.
format	article
author	Agnieszka Czechowicz Rahul Palchaudhuri Amelia Scheck Yu Hu Jonathan Hoggatt Borja Saez Wendy W. Pang Michael K. Mansour Tiffany A. Tate Yan Yi Chan Emily Walck Gerlinde Wernig Judith A. Shizuru Florian Winau David T. Scadden Derrick J. Rossi
author_facet	Agnieszka Czechowicz Rahul Palchaudhuri Amelia Scheck Yu Hu Jonathan Hoggatt Borja Saez Wendy W. Pang Michael K. Mansour Tiffany A. Tate Yan Yi Chan Emily Walck Gerlinde Wernig Judith A. Shizuru Florian Winau David T. Scadden Derrick J. Rossi
author_sort	Agnieszka Czechowicz
title	Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
title_short	Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
title_full	Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
title_fullStr	Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
title_full_unstemmed	Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
title_sort	selective hematopoietic stem cell ablation using cd117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9ffac621975f4bccb6eaeafd10b5ba55
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Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

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