Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonata...

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Autores principales:	Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
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spelling	oai:doaj.org-article:9ffc28868e0b404a868e8f4e98e9bbf72021-12-02T17:01:37ZIdentification of a potent benzoxaborole drug candidate for treating cryptosporidiosis10.1038/s41467-019-10687-y2041-1723https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf72019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10687-yhttps://doaj.org/toc/2041-1723Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonatal dairy calf disease models.Christopher S. LundeErin E. StebbinsRajiv S. JumaniMd Mahmudul HasanPeter MillerJohn BarlowYvonne R. FreundPamela BerryRianna StefanakisJiri GutPhilip J. RosenthalMelissa S. LoveCase W. McNamaraEric EasomJacob J. PlattnerRobert T. JacobsChristopher D. HustonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher S. Lunde Erin E. Stebbins Rajiv S. Jumani Md Mahmudul Hasan Peter Miller John Barlow Yvonne R. Freund Pamela Berry Rianna Stefanakis Jiri Gut Philip J. Rosenthal Melissa S. Love Case W. McNamara Eric Easom Jacob J. Plattner Robert T. Jacobs Christopher D. Huston Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
description	Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonatal dairy calf disease models.
format	article
author	Christopher S. Lunde Erin E. Stebbins Rajiv S. Jumani Md Mahmudul Hasan Peter Miller John Barlow Yvonne R. Freund Pamela Berry Rianna Stefanakis Jiri Gut Philip J. Rosenthal Melissa S. Love Case W. McNamara Eric Easom Jacob J. Plattner Robert T. Jacobs Christopher D. Huston
author_facet	Christopher S. Lunde Erin E. Stebbins Rajiv S. Jumani Md Mahmudul Hasan Peter Miller John Barlow Yvonne R. Freund Pamela Berry Rianna Stefanakis Jiri Gut Philip J. Rosenthal Melissa S. Love Case W. McNamara Eric Easom Jacob J. Plattner Robert T. Jacobs Christopher D. Huston
author_sort	Christopher S. Lunde
title	Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
title_short	Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
title_full	Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
title_fullStr	Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
title_full_unstemmed	Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
title_sort	identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
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Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

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