Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonata...
Guardado en:
Autores principales: | Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
por: Rajiv S. Jumani, et al.
Publicado: (2019) -
<named-content content-type="genus-species">Plasmodium falciparum</named-content> Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
por: Kirthana M. V. Sindhe, et al.
Publicado: (2020) -
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
por: Ebere Sonoiki, et al.
Publicado: (2017) -
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
por: Daniela Begolo, et al.
Publicado: (2018) -
Cryptosporidiosis and Colorectal Cancer
por: Sim Sai Tin, et al.
Publicado: (2015)