Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging. However, the roles of the changes in ECM characteristics and the molecules that are secreted to the extracellular...

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Autores principales:	Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	decellularization extracellular matrix matrisome skin development skin aging Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9ffd307b452d491584a6dcdba5095808
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spelling	oai:doaj.org-article:9ffd307b452d491584a6dcdba50958082021-12-01T07:11:02ZTime-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis2296-634X10.3389/fcell.2021.783456https://doaj.org/article/9ffd307b452d491584a6dcdba50958082021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.783456/fullhttps://doaj.org/toc/2296-634XSkin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging. However, the roles of the changes in ECM characteristics and the molecules that are secreted to the extracellular space and are involved in the formation of the dermal matrix from birth to old age remain unclear. To explore the way in which the ECM microenvironment supports the functions of skin development across different age groups is also poorly understood, we used a decellularization method and matrisome analysis to compare the composition, expression, and function of the dermal ECM in toddler, teenager, adult, and elderly skin. We found that the collagens, glycoproteins, proteoglycans, and regulatory factors that support skin development and interact with these core ECM proteins were differentially expressed at different ages. ECM expression markers occurring during the process of skin development were identified. In addition, our results elucidated the characteristics of ECM synthesis, response to skin development, and the features of the ECM that support epidermal stem cell growth via the basement membrane during skin aging.Mansheng LiXiao LiBinghui LiuLuye LvWenjuan WangDunqin GaoQiyu ZhangJunyi JiangMi ChaiZhimin YunYingxia TanFeng GongZhihong WuYunping ZhuYunping ZhuJie MaLing LengFrontiers Media S.A.articledecellularizationextracellular matrixmatrisomeskin developmentskin agingBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	decellularization extracellular matrix matrisome skin development skin aging Biology (General) QH301-705.5
spellingShingle	decellularization extracellular matrix matrisome skin development skin aging Biology (General) QH301-705.5 Mansheng Li Xiao Li Binghui Liu Luye Lv Wenjuan Wang Dunqin Gao Qiyu Zhang Junyi Jiang Mi Chai Zhimin Yun Yingxia Tan Feng Gong Zhihong Wu Yunping Zhu Yunping Zhu Jie Ma Ling Leng Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
description	Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging. However, the roles of the changes in ECM characteristics and the molecules that are secreted to the extracellular space and are involved in the formation of the dermal matrix from birth to old age remain unclear. To explore the way in which the ECM microenvironment supports the functions of skin development across different age groups is also poorly understood, we used a decellularization method and matrisome analysis to compare the composition, expression, and function of the dermal ECM in toddler, teenager, adult, and elderly skin. We found that the collagens, glycoproteins, proteoglycans, and regulatory factors that support skin development and interact with these core ECM proteins were differentially expressed at different ages. ECM expression markers occurring during the process of skin development were identified. In addition, our results elucidated the characteristics of ECM synthesis, response to skin development, and the features of the ECM that support epidermal stem cell growth via the basement membrane during skin aging.
format	article
author	Mansheng Li Xiao Li Binghui Liu Luye Lv Wenjuan Wang Dunqin Gao Qiyu Zhang Junyi Jiang Mi Chai Zhimin Yun Yingxia Tan Feng Gong Zhihong Wu Yunping Zhu Yunping Zhu Jie Ma Ling Leng
author_facet	Mansheng Li Xiao Li Binghui Liu Luye Lv Wenjuan Wang Dunqin Gao Qiyu Zhang Junyi Jiang Mi Chai Zhimin Yun Yingxia Tan Feng Gong Zhihong Wu Yunping Zhu Yunping Zhu Jie Ma Ling Leng
author_sort	Mansheng Li
title	Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
title_short	Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
title_full	Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
title_fullStr	Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
title_full_unstemmed	Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
title_sort	time-resolved extracellular matrix atlas of the developing human skin dermis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9ffd307b452d491584a6dcdba5095808
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Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

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