Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with STED with minimal phototoxicity.

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Autores principales: Xusan Yang, Zhigang Yang, Zhaoyang Wu, Ying He, Chunyan Shan, Peiyuan Chai, Chenshuo Ma, Mi Tian, Junlin Teng, Dayong Jin, Wei Yan, Pintu Das, Junle Qu, Peng Xi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9ffe6af77c4c4493a523b6faa6196cb7
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spelling oai:doaj.org-article:9ffe6af77c4c4493a523b6faa6196cb72021-12-02T16:43:46ZMitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe10.1038/s41467-020-17546-12041-1723https://doaj.org/article/9ffe6af77c4c4493a523b6faa6196cb72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17546-1https://doaj.org/toc/2041-1723Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with STED with minimal phototoxicity.Xusan YangZhigang YangZhaoyang WuYing HeChunyan ShanPeiyuan ChaiChenshuo MaMi TianJunlin TengDayong JinWei YanPintu DasJunle QuPeng XiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xusan Yang
Zhigang Yang
Zhaoyang Wu
Ying He
Chunyan Shan
Peiyuan Chai
Chenshuo Ma
Mi Tian
Junlin Teng
Dayong Jin
Wei Yan
Pintu Das
Junle Qu
Peng Xi
Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
description Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with STED with minimal phototoxicity.
format article
author Xusan Yang
Zhigang Yang
Zhaoyang Wu
Ying He
Chunyan Shan
Peiyuan Chai
Chenshuo Ma
Mi Tian
Junlin Teng
Dayong Jin
Wei Yan
Pintu Das
Junle Qu
Peng Xi
author_facet Xusan Yang
Zhigang Yang
Zhaoyang Wu
Ying He
Chunyan Shan
Peiyuan Chai
Chenshuo Ma
Mi Tian
Junlin Teng
Dayong Jin
Wei Yan
Pintu Das
Junle Qu
Peng Xi
author_sort Xusan Yang
title Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
title_short Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
title_full Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
title_fullStr Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
title_full_unstemmed Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
title_sort mitochondrial dynamics quantitatively revealed by sted nanoscopy with an enhanced squaraine variant probe
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9ffe6af77c4c4493a523b6faa6196cb7
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AT zhaoyangwu mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT yinghe mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT chunyanshan mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT peiyuanchai mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT chenshuoma mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT mitian mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT junlinteng mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT dayongjin mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT weiyan mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT pintudas mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT junlequ mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
AT pengxi mitochondrialdynamicsquantitativelyrevealedbystednanoscopywithanenhancedsquarainevariantprobe
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