Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marie-Victoire Guillot-Sestier, Ana Rubio Araiz, Virginia Mela, Aline Sayd Gaban, Eoin O’Neill, Lisha Joshi, Edward T. Chouchani, Evanna L. Mills, Marina A. Lynch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a001442647c94de9a36e380d0601a7a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a001442647c94de9a36e380d0601a7a1
record_format	dspace
spelling	oai:doaj.org-article:a001442647c94de9a36e380d0601a7a12021-12-02T17:34:48ZMicroglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease10.1038/s42003-021-02259-y2399-3642https://doaj.org/article/a001442647c94de9a36e380d0601a7a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02259-yhttps://doaj.org/toc/2399-3642Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD.Marie-Victoire Guillot-SestierAna Rubio AraizVirginia MelaAline Sayd GabanEoin O’NeillLisha JoshiEdward T. ChouchaniEvanna L. MillsMarina A. LynchNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
description	Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD.
format	article
author	Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch
author_facet	Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch
author_sort	Marie-Victoire Guillot-Sestier
title	Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_short	Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_full	Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_fullStr	Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_full_unstemmed	Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_sort	microglial metabolism is a pivotal factor in sexual dimorphism in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a001442647c94de9a36e380d0601a7a1
work_keys_str_mv	AT marievictoireguillotsestier microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT anarubioaraiz microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT virginiamela microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT alinesaydgaban microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT eoinoneill microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT lishajoshi microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT edwardtchouchani microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT evannalmills microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease AT marinaalynch microglialmetabolismisapivotalfactorinsexualdimorphisminalzheimersdisease
_version_	1718379957232599040

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

Ejemplares similares