CO2-sensitive tRNA modification associated with human mitochondrial disease

Transfer RNA modifications play critical roles in protein synthesis. Here the authors reveal the t6A37 tRNA modification is dynamically regulated by sensing intracellular CO2 concentration in mitochondria, implying metabolic regulation of protein synthesis.

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Autores principales:	Huan Lin, Kenjyo Miyauchi, Tai Harada, Ryo Okita, Eri Takeshita, Hirofumi Komaki, Kaoru Fujioka, Hideki Yagasaki, Yu-ichi Goto, Kaori Yanaka, Shinichi Nakagawa, Yuriko Sakaguchi, Tsutomu Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a003e4e93bed4afa8c4afc18c869c6bf
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spelling	oai:doaj.org-article:a003e4e93bed4afa8c4afc18c869c6bf2021-12-02T17:31:27ZCO2-sensitive tRNA modification associated with human mitochondrial disease10.1038/s41467-018-04250-42041-1723https://doaj.org/article/a003e4e93bed4afa8c4afc18c869c6bf2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04250-4https://doaj.org/toc/2041-1723Transfer RNA modifications play critical roles in protein synthesis. Here the authors reveal the t6A37 tRNA modification is dynamically regulated by sensing intracellular CO2 concentration in mitochondria, implying metabolic regulation of protein synthesis.Huan LinKenjyo MiyauchiTai HaradaRyo OkitaEri TakeshitaHirofumi KomakiKaoru FujiokaHideki YagasakiYu-ichi GotoKaori YanakaShinichi NakagawaYuriko SakaguchiTsutomu SuzukiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Lin Kenjyo Miyauchi Tai Harada Ryo Okita Eri Takeshita Hirofumi Komaki Kaoru Fujioka Hideki Yagasaki Yu-ichi Goto Kaori Yanaka Shinichi Nakagawa Yuriko Sakaguchi Tsutomu Suzuki CO2-sensitive tRNA modification associated with human mitochondrial disease
description	Transfer RNA modifications play critical roles in protein synthesis. Here the authors reveal the t6A37 tRNA modification is dynamically regulated by sensing intracellular CO2 concentration in mitochondria, implying metabolic regulation of protein synthesis.
format	article
author	Huan Lin Kenjyo Miyauchi Tai Harada Ryo Okita Eri Takeshita Hirofumi Komaki Kaoru Fujioka Hideki Yagasaki Yu-ichi Goto Kaori Yanaka Shinichi Nakagawa Yuriko Sakaguchi Tsutomu Suzuki
author_facet	Huan Lin Kenjyo Miyauchi Tai Harada Ryo Okita Eri Takeshita Hirofumi Komaki Kaoru Fujioka Hideki Yagasaki Yu-ichi Goto Kaori Yanaka Shinichi Nakagawa Yuriko Sakaguchi Tsutomu Suzuki
author_sort	Huan Lin
title	CO2-sensitive tRNA modification associated with human mitochondrial disease
title_short	CO2-sensitive tRNA modification associated with human mitochondrial disease
title_full	CO2-sensitive tRNA modification associated with human mitochondrial disease
title_fullStr	CO2-sensitive tRNA modification associated with human mitochondrial disease
title_full_unstemmed	CO2-sensitive tRNA modification associated with human mitochondrial disease
title_sort	co2-sensitive trna modification associated with human mitochondrial disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a003e4e93bed4afa8c4afc18c869c6bf
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CO2-sensitive tRNA modification associated with human mitochondrial disease

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