Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently....

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Autores principales:	Minsheng Wu, Meina He, Youmin Kang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	vitamin c foot-and-mouth disease vaccine efficacy Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a006988cb5674557bf17274316ae733b
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spelling	oai:doaj.org-article:a006988cb5674557bf17274316ae733b2021-11-26T11:19:46ZVitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine0954-01051465-344310.1080/09540105.2017.1406459https://doaj.org/article/a006988cb5674557bf17274316ae733b2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1406459https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently. In this study, we evaluated the biological function of VC on immune response to inactivated foot-and-mouth disease (FMD) vaccine. The C57BL/6 mice were injected intraperitoneally with different dose of VC daily following immunization with inactivated FMD vaccine. The results showed high dose of VC supplementation significantly increased IgG level. Similarly, high dose of VC supplementation enhanced Th2 and Th17 cellular immune responses and also increased MHCII expression on dendritic cells. Taken together, these data indicate that high dose of VC supplementation can modulate Th2 and Th17 cellular immune responses to inactivated FMD vaccine and manifest the necessity for effective vaccination.Minsheng WuMeina HeYoumin KangTaylor & Francis Grouparticlevitamin cfoot-and-mouth diseasevaccineefficacyAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 470-483 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin c foot-and-mouth disease vaccine efficacy Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	vitamin c foot-and-mouth disease vaccine efficacy Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Minsheng Wu Meina He Youmin Kang Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
description	Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently. In this study, we evaluated the biological function of VC on immune response to inactivated foot-and-mouth disease (FMD) vaccine. The C57BL/6 mice were injected intraperitoneally with different dose of VC daily following immunization with inactivated FMD vaccine. The results showed high dose of VC supplementation significantly increased IgG level. Similarly, high dose of VC supplementation enhanced Th2 and Th17 cellular immune responses and also increased MHCII expression on dendritic cells. Taken together, these data indicate that high dose of VC supplementation can modulate Th2 and Th17 cellular immune responses to inactivated FMD vaccine and manifest the necessity for effective vaccination.
format	article
author	Minsheng Wu Meina He Youmin Kang
author_facet	Minsheng Wu Meina He Youmin Kang
author_sort	Minsheng Wu
title	Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
title_short	Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
title_full	Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
title_fullStr	Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
title_full_unstemmed	Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine
title_sort	vitamin c supplementation improved the efficacy of foot-and-mouth disease vaccine
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/a006988cb5674557bf17274316ae733b
work_keys_str_mv	AT minshengwu vitamincsupplementationimprovedtheefficacyoffootandmouthdiseasevaccine AT meinahe vitamincsupplementationimprovedtheefficacyoffootandmouthdiseasevaccine AT youminkang vitamincsupplementationimprovedtheefficacyoffootandmouthdiseasevaccine
_version_	1718409551884058624

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

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