Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective

ABSTRACT The recognition over the past decade that nearly all diseases are associated with changes in the microbiome has raised hope that microbiome-based therapeutics may cure many human ailments. Billions of dollars are being poured into microbiome-oriented biotech companies, and the coming years...

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Autor principal:	Neeraj K. Surana
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	clinical therapeutics microbiome translation Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a009400b90b642e5a878882640a75b51
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spelling	oai:doaj.org-article:a009400b90b642e5a878882640a75b512021-12-02T19:47:35ZMoving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective10.1128/mSystems.00160-192379-5077https://doaj.org/article/a009400b90b642e5a878882640a75b512019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00160-19https://doaj.org/toc/2379-5077ABSTRACT The recognition over the past decade that nearly all diseases are associated with changes in the microbiome has raised hope that microbiome-based therapeutics may cure many human ailments. Billions of dollars are being poured into microbiome-oriented biotech companies, and the coming years will undoubtedly witness the approval of the first generation of these products. However, significant hurdles remain in expanding the pipeline and advancing these first-generation therapies. In this perspective, I will discuss the challenges related to identifying causal microbes, determining their mechanism of action, and characterizing the specific bacterial molecules required for disease protection. We are approaching these issues through a combination of clinical sampling, animal models, classic microbiology methodologies, and systems-based approaches. The field of microbiome research is on the cusp of being able to identify clinically actionable host-microbe relationships; increasing attention on identifying causal microbes and their bioactive factors will usher in the next generation of microbiome-based therapies.Neeraj K. SuranaAmerican Society for Microbiologyarticleclinical therapeuticsmicrobiometranslationMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical therapeutics microbiome translation Microbiology QR1-502
spellingShingle	clinical therapeutics microbiome translation Microbiology QR1-502 Neeraj K. Surana Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
description	ABSTRACT The recognition over the past decade that nearly all diseases are associated with changes in the microbiome has raised hope that microbiome-based therapeutics may cure many human ailments. Billions of dollars are being poured into microbiome-oriented biotech companies, and the coming years will undoubtedly witness the approval of the first generation of these products. However, significant hurdles remain in expanding the pipeline and advancing these first-generation therapies. In this perspective, I will discuss the challenges related to identifying causal microbes, determining their mechanism of action, and characterizing the specific bacterial molecules required for disease protection. We are approaching these issues through a combination of clinical sampling, animal models, classic microbiology methodologies, and systems-based approaches. The field of microbiome research is on the cusp of being able to identify clinically actionable host-microbe relationships; increasing attention on identifying causal microbes and their bioactive factors will usher in the next generation of microbiome-based therapies.
format	article
author	Neeraj K. Surana
author_facet	Neeraj K. Surana
author_sort	Neeraj K. Surana
title	Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
title_short	Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
title_full	Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
title_fullStr	Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
title_full_unstemmed	Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective
title_sort	moving microbiome science from the bench to the bedside: a physician-scientist perspective
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/a009400b90b642e5a878882640a75b51
work_keys_str_mv	AT neerajksurana movingmicrobiomesciencefromthebenchtothebedsideaphysicianscientistperspective
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Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective

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