Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box

The choline-binding protein ChoX exhibits a synergistic dual-site binding mode that allows it to discriminate choline over structural analogues. Here, the authors design a biomimetic triple anion helicate receptor whose selectivity for choline arises from a similar binding mechanism.

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Autores principales:	Chuandong Jia, Wei Zuo, Dong Yang, Yanming Chen, Liping Cao, Radu Custelcean, Jiří Hostaš, Pavel Hobza, Robert Glaser, Yao-Yu Wang, Xiao-Juan Yang, Biao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a00ae0061f674f4880e6a5d81d7d050f
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spelling	oai:doaj.org-article:a00ae0061f674f4880e6a5d81d7d050f2021-12-02T14:43:00ZSelective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box10.1038/s41467-017-00915-82041-1723https://doaj.org/article/a00ae0061f674f4880e6a5d81d7d050f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00915-8https://doaj.org/toc/2041-1723The choline-binding protein ChoX exhibits a synergistic dual-site binding mode that allows it to discriminate choline over structural analogues. Here, the authors design a biomimetic triple anion helicate receptor whose selectivity for choline arises from a similar binding mechanism.Chuandong JiaWei ZuoDong YangYanming ChenLiping CaoRadu CustelceanJiří HostašPavel HobzaRobert GlaserYao-Yu WangXiao-Juan YangBiao WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuandong Jia Wei Zuo Dong Yang Yanming Chen Liping Cao Radu Custelcean Jiří Hostaš Pavel Hobza Robert Glaser Yao-Yu Wang Xiao-Juan Yang Biao Wu Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
description	The choline-binding protein ChoX exhibits a synergistic dual-site binding mode that allows it to discriminate choline over structural analogues. Here, the authors design a biomimetic triple anion helicate receptor whose selectivity for choline arises from a similar binding mechanism.
format	article
author	Chuandong Jia Wei Zuo Dong Yang Yanming Chen Liping Cao Radu Custelcean Jiří Hostaš Pavel Hobza Robert Glaser Yao-Yu Wang Xiao-Juan Yang Biao Wu
author_facet	Chuandong Jia Wei Zuo Dong Yang Yanming Chen Liping Cao Radu Custelcean Jiří Hostaš Pavel Hobza Robert Glaser Yao-Yu Wang Xiao-Juan Yang Biao Wu
author_sort	Chuandong Jia
title	Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
title_short	Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
title_full	Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
title_fullStr	Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
title_full_unstemmed	Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
title_sort	selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a00ae0061f674f4880e6a5d81d7d050f
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Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box

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