Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer

Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment.

Guardado en:
Detalles Bibliográficos
Autores principales: Carol Lai-Hung Cheng, Felice Hoi-Ching Tsang, Lai Wei, Mengnuo Chen, Don Wai-Ching Chin, Jialing Shen, Cheuk-Ting Law, Derek Lee, Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Chun-Ming Wong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Acceso en línea:https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a00c4f2a8e644de8ab49c7c3c780d42a
record_format dspace
spelling oai:doaj.org-article:a00c4f2a8e644de8ab49c7c3c780d42a2021-12-02T17:55:11ZBromodomain-containing protein BRPF1 is a therapeutic target for liver cancer10.1038/s42003-021-02405-62399-3642https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02405-6https://doaj.org/toc/2399-3642Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment.Carol Lai-Hung ChengFelice Hoi-Ching TsangLai WeiMengnuo ChenDon Wai-Ching ChinJialing ShenCheuk-Ting LawDerek LeeCarmen Chak-Lui WongIrene Oi-Lin NgChun-Ming WongNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Carol Lai-Hung Cheng
Felice Hoi-Ching Tsang
Lai Wei
Mengnuo Chen
Don Wai-Ching Chin
Jialing Shen
Cheuk-Ting Law
Derek Lee
Carmen Chak-Lui Wong
Irene Oi-Lin Ng
Chun-Ming Wong
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
description Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment.
format article
author Carol Lai-Hung Cheng
Felice Hoi-Ching Tsang
Lai Wei
Mengnuo Chen
Don Wai-Ching Chin
Jialing Shen
Cheuk-Ting Law
Derek Lee
Carmen Chak-Lui Wong
Irene Oi-Lin Ng
Chun-Ming Wong
author_facet Carol Lai-Hung Cheng
Felice Hoi-Ching Tsang
Lai Wei
Mengnuo Chen
Don Wai-Ching Chin
Jialing Shen
Cheuk-Ting Law
Derek Lee
Carmen Chak-Lui Wong
Irene Oi-Lin Ng
Chun-Ming Wong
author_sort Carol Lai-Hung Cheng
title Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
title_short Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
title_full Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
title_fullStr Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
title_full_unstemmed Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
title_sort bromodomain-containing protein brpf1 is a therapeutic target for liver cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a
work_keys_str_mv AT carollaihungcheng bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT felicehoichingtsang bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT laiwei bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT mengnuochen bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT donwaichingchin bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT jialingshen bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT cheuktinglaw bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT dereklee bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT carmenchakluiwong bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT ireneoilinng bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
AT chunmingwong bromodomaincontainingproteinbrpf1isatherapeutictargetforlivercancer
_version_ 1718379125267234816