Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment.
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Nature Portfolio
2021
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oai:doaj.org-article:a00c4f2a8e644de8ab49c7c3c780d42a2021-12-02T17:55:11ZBromodomain-containing protein BRPF1 is a therapeutic target for liver cancer10.1038/s42003-021-02405-62399-3642https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02405-6https://doaj.org/toc/2399-3642Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment.Carol Lai-Hung ChengFelice Hoi-Ching TsangLai WeiMengnuo ChenDon Wai-Ching ChinJialing ShenCheuk-Ting LawDerek LeeCarmen Chak-Lui WongIrene Oi-Lin NgChun-Ming WongNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
institution |
DOAJ |
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DOAJ |
language |
EN |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Carol Lai-Hung Cheng Felice Hoi-Ching Tsang Lai Wei Mengnuo Chen Don Wai-Ching Chin Jialing Shen Cheuk-Ting Law Derek Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
description |
Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting it might serve as a strategy for cancer treatment. |
format |
article |
author |
Carol Lai-Hung Cheng Felice Hoi-Ching Tsang Lai Wei Mengnuo Chen Don Wai-Ching Chin Jialing Shen Cheuk-Ting Law Derek Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong |
author_facet |
Carol Lai-Hung Cheng Felice Hoi-Ching Tsang Lai Wei Mengnuo Chen Don Wai-Ching Chin Jialing Shen Cheuk-Ting Law Derek Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong |
author_sort |
Carol Lai-Hung Cheng |
title |
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
title_short |
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
title_full |
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
title_fullStr |
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
title_full_unstemmed |
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer |
title_sort |
bromodomain-containing protein brpf1 is a therapeutic target for liver cancer |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a |
work_keys_str_mv |
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