Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling and inhibits protein synthesis.

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Autores principales:	Mehdi Eshraghi, Pabalu P. Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P. Ricci, Audrey Michel, Nicolai T. Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramaniam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a00d7181daf04071b4b42dae11f057fa
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spelling	oai:doaj.org-article:a00d7181daf04071b4b42dae11f057fa2021-12-02T13:33:01ZMutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease10.1038/s41467-021-21637-y2041-1723https://doaj.org/article/a00d7181daf04071b4b42dae11f057fa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21637-yhttps://doaj.org/toc/2041-1723Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling and inhibits protein synthesis.Mehdi EshraghiPabalu P. KarunadharmaJuliana BlinNeelam ShahaniEmiliano P. RicciAudrey MichelNicolai T. UrbanNicole GalliManish SharmaUri Nimrod Ramírez-JarquínKatie FlorescuJennifer HernandezSrinivasa SubramaniamNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mehdi Eshraghi Pabalu P. Karunadharma Juliana Blin Neelam Shahani Emiliano P. Ricci Audrey Michel Nicolai T. Urban Nicole Galli Manish Sharma Uri Nimrod Ramírez-Jarquín Katie Florescu Jennifer Hernandez Srinivasa Subramaniam Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
description	Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling and inhibits protein synthesis.
format	article
author	Mehdi Eshraghi Pabalu P. Karunadharma Juliana Blin Neelam Shahani Emiliano P. Ricci Audrey Michel Nicolai T. Urban Nicole Galli Manish Sharma Uri Nimrod Ramírez-Jarquín Katie Florescu Jennifer Hernandez Srinivasa Subramaniam
author_facet	Mehdi Eshraghi Pabalu P. Karunadharma Juliana Blin Neelam Shahani Emiliano P. Ricci Audrey Michel Nicolai T. Urban Nicole Galli Manish Sharma Uri Nimrod Ramírez-Jarquín Katie Florescu Jennifer Hernandez Srinivasa Subramaniam
author_sort	Mehdi Eshraghi
title	Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
title_short	Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
title_full	Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
title_fullStr	Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
title_full_unstemmed	Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
title_sort	mutant huntingtin stalls ribosomes and represses protein synthesis in a cellular model of huntington disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a00d7181daf04071b4b42dae11f057fa
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Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

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