Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma

Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differen...

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Autores principales:	Zhi-Yong Yao, Chaoqung Xing, Yuan-Wu Liu, Xiao-Liang Xing
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	KIRC DEGs DMPS immune-related prognosis Genetics QH426-470
Acceso en línea:	https://doaj.org/article/a00eef66941149b9b143a98a63c7ce25
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spelling	oai:doaj.org-article:a00eef66941149b9b143a98a63c7ce252021-12-02T09:46:49ZIdentification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma1664-802110.3389/fgene.2021.750997https://doaj.org/article/a00eef66941149b9b143a98a63c7ce252021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.750997/fullhttps://doaj.org/toc/1664-8021Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differentially expressed genes (IR-DEGs) associated with aberrant methylations and construct a risk assessment model using these IR-DEGs to predict the prognosis of KIRC. Two IR-DEGs (SLC11A1 and TNFSF14) were identified by differential expression, correlation analysis, and Cox regression analysis, and risk assessment models were established. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.6907. In addition, we found that risk scores were significantly associated with 31 immune cells and factors. Our present study not only shows that two IR-DEGs can be used as prognosis signatures for KIRC, but also provides a strategy for the screening of suitable prognosis signatures associated with aberrant methylation in other cancers.Zhi-Yong YaoZhi-Yong YaoChaoqung XingYuan-Wu LiuXiao-Liang XingXiao-Liang XingFrontiers Media S.A.articleKIRCDEGsDMPSimmune-relatedprognosisGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	KIRC DEGs DMPS immune-related prognosis Genetics QH426-470
spellingShingle	KIRC DEGs DMPS immune-related prognosis Genetics QH426-470 Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
description	Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differentially expressed genes (IR-DEGs) associated with aberrant methylations and construct a risk assessment model using these IR-DEGs to predict the prognosis of KIRC. Two IR-DEGs (SLC11A1 and TNFSF14) were identified by differential expression, correlation analysis, and Cox regression analysis, and risk assessment models were established. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.6907. In addition, we found that risk scores were significantly associated with 31 immune cells and factors. Our present study not only shows that two IR-DEGs can be used as prognosis signatures for KIRC, but also provides a strategy for the screening of suitable prognosis signatures associated with aberrant methylation in other cancers.
format	article
author	Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing
author_facet	Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing
author_sort	Zhi-Yong Yao
title	Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
title_short	Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
title_full	Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
title_fullStr	Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
title_full_unstemmed	Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
title_sort	identification of two immune related genes correlated with aberrant methylations as prognosis signatures for renal clear cell carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a00eef66941149b9b143a98a63c7ce25
work_keys_str_mv	AT zhiyongyao identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma AT zhiyongyao identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma AT chaoqungxing identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma AT yuanwuliu identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma AT xiaoliangxing identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma AT xiaoliangxing identificationoftwoimmunerelatedgenescorrelatedwithaberrantmethylationsasprognosissignaturesforrenalclearcellcarcinoma
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Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma

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