Physicochemical characterization of drug nanocarriers

Eloísa Berbel Manaia,1 Marina Paiva Abuçafy,1 Bruna Galdorfini Chiari-Andréo,1,2 Bruna Lallo Silva,1 João Augusto Oshiro Junior,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State...

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Autores principales:	Manaia EB, Abuçafy MP, Chiari-Andréo BG, Silva BL, Oshiro Junior JA, Chiavacci LA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Nanoparticles drug delivery physicochemical properties controlled release of drugs Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a01496a6e51f44b9a89ad8c325dadd3c
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spelling	oai:doaj.org-article:a01496a6e51f44b9a89ad8c325dadd3c2021-12-02T00:31:21ZPhysicochemical characterization of drug nanocarriers1178-2013https://doaj.org/article/a01496a6e51f44b9a89ad8c325dadd3c2017-07-01T00:00:00Zhttps://www.dovepress.com/physicochemical-characterization-of-drug-nanocarriers-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Eloísa Berbel Manaia,1 Marina Paiva Abuçafy,1 Bruna Galdorfini Chiari-Andréo,1,2 Bruna Lallo Silva,1 João Augusto Oshiro Junior,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil, 2Department of Biological and Health Sciences, Centro Universitário de Araraquara, UNIARA, Araraquara, SP, Brazil Abstract: Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical properties, which greatly influence their behavior in the body at both the molecular and systemic levels. This review was conducted to describe the principles and characteristics of techniques commonly used to elucidate the structures of nanocarriers, with consideration of their size, morphology, surface charge, porosity, crystalline arrangement, and phase. These techniques include X-ray diffraction, small-angle X-ray scattering, dynamic light scattering, zeta potential, polarized light microscopy, transmission electron microscopy, scanning electron microcopy, and porosimetry. Moreover, we describe some of the commonly used nanocarriers (liquid crystals, metal–organic frameworks, silica nanospheres, liposomes, solid lipid nanoparticles, and micelles) and the main aspects of their structures. Keywords: nanoparticles, drug delivery, physicochemical properties, controlled drug releaseManaia EBAbuçafy MPChiari-Andréo BGSilva BLOshiro Junior JAChiavacci LADove Medical PressarticleNanoparticlesdrug deliveryphysicochemical propertiescontrolled release of drugsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4991-5011 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanoparticles drug delivery physicochemical properties controlled release of drugs Medicine (General) R5-920
spellingShingle	Nanoparticles drug delivery physicochemical properties controlled release of drugs Medicine (General) R5-920 Manaia EB Abuçafy MP Chiari-Andréo BG Silva BL Oshiro Junior JA Chiavacci LA Physicochemical characterization of drug nanocarriers
description	Eloísa Berbel Manaia,1 Marina Paiva Abuçafy,1 Bruna Galdorfini Chiari-Andréo,1,2 Bruna Lallo Silva,1 João Augusto Oshiro Junior,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil, 2Department of Biological and Health Sciences, Centro Universitário de Araraquara, UNIARA, Araraquara, SP, Brazil Abstract: Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical properties, which greatly influence their behavior in the body at both the molecular and systemic levels. This review was conducted to describe the principles and characteristics of techniques commonly used to elucidate the structures of nanocarriers, with consideration of their size, morphology, surface charge, porosity, crystalline arrangement, and phase. These techniques include X-ray diffraction, small-angle X-ray scattering, dynamic light scattering, zeta potential, polarized light microscopy, transmission electron microscopy, scanning electron microcopy, and porosimetry. Moreover, we describe some of the commonly used nanocarriers (liquid crystals, metal–organic frameworks, silica nanospheres, liposomes, solid lipid nanoparticles, and micelles) and the main aspects of their structures. Keywords: nanoparticles, drug delivery, physicochemical properties, controlled drug release
format	article
author	Manaia EB Abuçafy MP Chiari-Andréo BG Silva BL Oshiro Junior JA Chiavacci LA
author_facet	Manaia EB Abuçafy MP Chiari-Andréo BG Silva BL Oshiro Junior JA Chiavacci LA
author_sort	Manaia EB
title	Physicochemical characterization of drug nanocarriers
title_short	Physicochemical characterization of drug nanocarriers
title_full	Physicochemical characterization of drug nanocarriers
title_fullStr	Physicochemical characterization of drug nanocarriers
title_full_unstemmed	Physicochemical characterization of drug nanocarriers
title_sort	physicochemical characterization of drug nanocarriers
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a01496a6e51f44b9a89ad8c325dadd3c
work_keys_str_mv	AT manaiaeb physicochemicalcharacterizationofdrugnanocarriers AT abucafymp physicochemicalcharacterizationofdrugnanocarriers AT chiariandreobg physicochemicalcharacterizationofdrugnanocarriers AT silvabl physicochemicalcharacterizationofdrugnanocarriers AT oshirojuniorja physicochemicalcharacterizationofdrugnanocarriers AT chiavaccila physicochemicalcharacterizationofdrugnanocarriers
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Physicochemical characterization of drug nanocarriers

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