Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia

Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia

Abstract Motivational deficits play a central role in disability due to negative symptoms of schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed therapeutic development. We applied an fMRI Effort Discounting Task (EDT) that quantifies motivation using a neuroec...

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Autores principales: Greer E. Prettyman, Joseph W. Kable, Paige Didier, Sheila Shankar, Theodore D. Satterthwaite, Christos Davatzikos, Warren B. Bilker, Mark A. Elliott, Kosha Ruparel, Daniel H. Wolf
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Psychiatry
RC435-571
Acceso en línea:https://doaj.org/article/a0155da9ab6d4263a3f7852965137986
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