The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan

Yu-Shan Lee,1 Lee-Ching Hwang,1,2 Hsin-Yin Hsu,1 Meng-Ting Tsou1,3 1Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; 3Mackay Junior College of Medicine, Nursing, and Management, Taipei, TaiwanCorrespond...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lee YS, Hwang LC, Hsu HY, Tsou MT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nonalcoholic fatty liver disease obese phenotype elderly population nafld fibrosis score fibrosis-4 Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/a01579c370d040c68e8100b32150845e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a01579c370d040c68e8100b32150845e
record_format	dspace
spelling	oai:doaj.org-article:a01579c370d040c68e8100b32150845e2021-12-02T14:51:57ZThe Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan1178-7007https://doaj.org/article/a01579c370d040c68e8100b32150845e2021-03-01T00:00:00Zhttps://www.dovepress.com/the-association-between-different-obesity-phenotypes-and-liver-fibrosi-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yu-Shan Lee,1 Lee-Ching Hwang,1,2 Hsin-Yin Hsu,1 Meng-Ting Tsou1,3 1Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; 3Mackay Junior College of Medicine, Nursing, and Management, Taipei, TaiwanCorrespondence: Meng-Ting TsouDepartment of Family Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Taipei City, 10449, Taiwan, R.O.C.Tel +886 2 2543 3535 (Ext. 2131 or 2132)Fax +886 2 2543 3642Email mttsou@gmail.comPurpose: To examine the association between different phenotypes of obesity or metabolic syndromes and liver fibrosis score in a Taiwanese elderly population with fatty liver.Patients and Methods: This cross-sectional study included 1817 participants aged ≥ 65 years with fatty liver diagnosed by sonography. We used ethnicity-specific criteria for body mass index and metabolic syndrome, and to define obesity phenotypes as metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Correlated fibrosis severity was calculated using the nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) and Fibrosis-4 (FIB-4). Fibrosis severity was divided into two categories according to NFS (no-to-mild fibrosis and advanced fibrosis, defined as NFS ≤ 0.676 and > 0.676, respectively) and FIB-4 score (no-to-mild fibrosis and advanced fibrosis, defined as FIB-4 score ≤ 2.67 and > 2.67, respectively).Results: Compared with that in the MHNO group, the associated risk (odds ratio [OR], 95% confidence interval [CI]) of advanced fibrosis by NFS was 2.43 (1.50– 3.93), 2.35 (1.25– 4.41), and 6.11 (3.90– 9.59), whereas that of advanced fibrosis by FIB-4 score was 1.34 (0.83– 2.18), 2.37 (1.36– 4.13), and 1.38 (0.82– 2.31) in the MUNO, MHO, and MUO groups, respectively.Conclusion: Both metabolic syndrome and obesity were positively associated with more advanced fibrosis according to NFS. The detrimental effect of obesity appears to be more than metabolic abnormalities per se in the elderly with more advanced fibrosis severity according to the FIB-4 score.Keywords: nonalcoholic fatty liver disease, obese phenotype, elderly population, NAFLD fibrosis score, Fibrosis-4Lee YSHwang LCHsu HYTsou MTDove Medical Pressarticlenonalcoholic fatty liver diseaseobese phenotypeelderly populationnafld fibrosis scorefibrosis-4Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1473-1483 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonalcoholic fatty liver disease obese phenotype elderly population nafld fibrosis score fibrosis-4 Specialties of internal medicine RC581-951
spellingShingle	nonalcoholic fatty liver disease obese phenotype elderly population nafld fibrosis score fibrosis-4 Specialties of internal medicine RC581-951 Lee YS Hwang LC Hsu HY Tsou MT The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
description	Yu-Shan Lee,1 Lee-Ching Hwang,1,2 Hsin-Yin Hsu,1 Meng-Ting Tsou1,3 1Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; 3Mackay Junior College of Medicine, Nursing, and Management, Taipei, TaiwanCorrespondence: Meng-Ting TsouDepartment of Family Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Taipei City, 10449, Taiwan, R.O.C.Tel +886 2 2543 3535 (Ext. 2131 or 2132)Fax +886 2 2543 3642Email mttsou@gmail.comPurpose: To examine the association between different phenotypes of obesity or metabolic syndromes and liver fibrosis score in a Taiwanese elderly population with fatty liver.Patients and Methods: This cross-sectional study included 1817 participants aged ≥ 65 years with fatty liver diagnosed by sonography. We used ethnicity-specific criteria for body mass index and metabolic syndrome, and to define obesity phenotypes as metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Correlated fibrosis severity was calculated using the nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) and Fibrosis-4 (FIB-4). Fibrosis severity was divided into two categories according to NFS (no-to-mild fibrosis and advanced fibrosis, defined as NFS ≤ 0.676 and > 0.676, respectively) and FIB-4 score (no-to-mild fibrosis and advanced fibrosis, defined as FIB-4 score ≤ 2.67 and > 2.67, respectively).Results: Compared with that in the MHNO group, the associated risk (odds ratio [OR], 95% confidence interval [CI]) of advanced fibrosis by NFS was 2.43 (1.50– 3.93), 2.35 (1.25– 4.41), and 6.11 (3.90– 9.59), whereas that of advanced fibrosis by FIB-4 score was 1.34 (0.83– 2.18), 2.37 (1.36– 4.13), and 1.38 (0.82– 2.31) in the MUNO, MHO, and MUO groups, respectively.Conclusion: Both metabolic syndrome and obesity were positively associated with more advanced fibrosis according to NFS. The detrimental effect of obesity appears to be more than metabolic abnormalities per se in the elderly with more advanced fibrosis severity according to the FIB-4 score.Keywords: nonalcoholic fatty liver disease, obese phenotype, elderly population, NAFLD fibrosis score, Fibrosis-4
format	article
author	Lee YS Hwang LC Hsu HY Tsou MT
author_facet	Lee YS Hwang LC Hsu HY Tsou MT
author_sort	Lee YS
title	The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
title_short	The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
title_full	The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
title_fullStr	The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
title_full_unstemmed	The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan
title_sort	association between different obesity phenotypes and liver fibrosis scores in elderly individuals with fatty liver in taiwan
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a01579c370d040c68e8100b32150845e
work_keys_str_mv	AT leeys theassociationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT hwanglc theassociationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT hsuhy theassociationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT tsoumt theassociationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT leeys associationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT hwanglc associationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT hsuhy associationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan AT tsoumt associationbetweendifferentobesityphenotypesandliverfibrosisscoresinelderlyindividualswithfattyliverintaiwan
_version_	1718389464653365248

The Association Between Different Obesity Phenotypes and Liver Fibrosis Scores in Elderly Individuals with Fatty Liver in Taiwan

Ejemplares similares