Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas

Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differe...

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Autores principales:	Mthabisi B. Moyo, J. Brandon Parker, Debabrata Chakravarti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a01835de97ba44deb1d5266b194a1767
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spelling	oai:doaj.org-article:a01835de97ba44deb1d5266b194a17672021-12-02T14:28:23ZAltered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas10.1038/s41467-020-14701-62041-1723https://doaj.org/article/a01835de97ba44deb1d5266b194a17672020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14701-6https://doaj.org/toc/2041-1723Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas.Mthabisi B. MoyoJ. Brandon ParkerDebabrata ChakravartiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
description	Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas.
format	article
author	Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti
author_facet	Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti
author_sort	Mthabisi B. Moyo
title	Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
title_short	Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
title_full	Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
title_fullStr	Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
title_full_unstemmed	Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
title_sort	altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in med12 mutant uterine leiomyomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a01835de97ba44deb1d5266b194a1767
work_keys_str_mv	AT mthabisibmoyo alteredchromatinlandscapeandenhancerengagementunderlietranscriptionaldysregulationinmed12mutantuterineleiomyomas AT jbrandonparker alteredchromatinlandscapeandenhancerengagementunderlietranscriptionaldysregulationinmed12mutantuterineleiomyomas AT debabratachakravarti alteredchromatinlandscapeandenhancerengagementunderlietranscriptionaldysregulationinmed12mutantuterineleiomyomas
_version_	1718391269615468544

Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas

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