Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.

It can be difficult for anesthesiologists to determine the optimal dose of propofol for end-stage kidney disease (ESKD) patients due to changes in drug disposition. The purpose of this study was to evaluate the potency of propofol for inducing loss of consciousness in ESKD patients. Patients with no...

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Autores principales:	Mi Roung Jun, Mun Gyu Kim, Ki Seob Han, Ji Eun Park, Ho Bum Cho, Sun Young Park, Sanghoon Song, Jae Hwa Yoo, Ji Won Chung, Sang Ho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a01af8907d5940c083dcba43ad5fffa8
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spelling	oai:doaj.org-article:a01af8907d5940c083dcba43ad5fffa82021-12-02T20:18:20ZPotency of propofol for inducing loss of consciousness in end-stage kidney disease patients.1932-620310.1371/journal.pone.0254520https://doaj.org/article/a01af8907d5940c083dcba43ad5fffa82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254520https://doaj.org/toc/1932-6203It can be difficult for anesthesiologists to determine the optimal dose of propofol for end-stage kidney disease (ESKD) patients due to changes in drug disposition. The purpose of this study was to evaluate the potency of propofol for inducing loss of consciousness in ESKD patients. Patients with normal kidney function (Control group, n = 15), those with ESKD (ESKD group, n = 15), and those with ESKD undergoing cervical epidural anesthesia (ESKD-CEB group, n = 15) were administered propofol by target-controlled infusion (TCI) using the Schneider model. The effect-site concentration (Ce) of propofol started at 0.5 μg/ml and increased in increments of 0.5 μg/ml until the patient did not respond to verbal commands. The relationship between the probability (P) of loss of consciousness and the Ce of propofol was analyzed in each group using logistic regression. The Ce values of propofol at the time of loss of consciousness were 4.3 ± 0.9, 3.7 ± 0.9, and 3.3 ± 1.0 μg/ml for the Control, ESKD, and ESKD-CEB* groups, respectively (*significant difference vs. control, P < 0.05). The estimated Ce50 values for lost ability to respond to verbal command were 4.56, 3.75, and 3.21 μg/ml for the Control, ESKD, and ESKD-CEB groups, respectively. In conclusion, when inducing anesthesia in ESKD patients, we recommend using an initial dose similar to that of patients with normal kidney function, or rather starting with a lower dose.Mi Roung JunMun Gyu KimKi Seob HanJi Eun ParkHo Bum ChoSun Young ParkSanghoon SongJae Hwa YooJi Won ChungSang Ho KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254520 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mi Roung Jun Mun Gyu Kim Ki Seob Han Ji Eun Park Ho Bum Cho Sun Young Park Sanghoon Song Jae Hwa Yoo Ji Won Chung Sang Ho Kim Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
description	It can be difficult for anesthesiologists to determine the optimal dose of propofol for end-stage kidney disease (ESKD) patients due to changes in drug disposition. The purpose of this study was to evaluate the potency of propofol for inducing loss of consciousness in ESKD patients. Patients with normal kidney function (Control group, n = 15), those with ESKD (ESKD group, n = 15), and those with ESKD undergoing cervical epidural anesthesia (ESKD-CEB group, n = 15) were administered propofol by target-controlled infusion (TCI) using the Schneider model. The effect-site concentration (Ce) of propofol started at 0.5 μg/ml and increased in increments of 0.5 μg/ml until the patient did not respond to verbal commands. The relationship between the probability (P) of loss of consciousness and the Ce of propofol was analyzed in each group using logistic regression. The Ce values of propofol at the time of loss of consciousness were 4.3 ± 0.9, 3.7 ± 0.9, and 3.3 ± 1.0 μg/ml for the Control, ESKD, and ESKD-CEB* groups, respectively (*significant difference vs. control, P < 0.05). The estimated Ce50 values for lost ability to respond to verbal command were 4.56, 3.75, and 3.21 μg/ml for the Control, ESKD, and ESKD-CEB groups, respectively. In conclusion, when inducing anesthesia in ESKD patients, we recommend using an initial dose similar to that of patients with normal kidney function, or rather starting with a lower dose.
format	article
author	Mi Roung Jun Mun Gyu Kim Ki Seob Han Ji Eun Park Ho Bum Cho Sun Young Park Sanghoon Song Jae Hwa Yoo Ji Won Chung Sang Ho Kim
author_facet	Mi Roung Jun Mun Gyu Kim Ki Seob Han Ji Eun Park Ho Bum Cho Sun Young Park Sanghoon Song Jae Hwa Yoo Ji Won Chung Sang Ho Kim
author_sort	Mi Roung Jun
title	Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
title_short	Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
title_full	Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
title_fullStr	Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
title_full_unstemmed	Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
title_sort	potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a01af8907d5940c083dcba43ad5fffa8
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Potency of propofol for inducing loss of consciousness in end-stage kidney disease patients.

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