MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.

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Autores principales:	RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh, Sudarshan Anand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a01c9f15bea14236bb83264f01ebc409
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spelling	oai:doaj.org-article:a01c9f15bea14236bb83264f01ebc4092021-12-02T16:56:47ZMicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment10.1038/ncomms135972041-1723https://doaj.org/article/a01c9f15bea14236bb83264f01ebc4092016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13597https://doaj.org/toc/2041-1723The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.RaeAnna WilsonCristina Espinosa-DiezNathan KannerNamita ChatterjeeRebecca RuhlChristina HipfingerSunil J. AdvaniJie LiOmar F. KhanAleksandra FranovicSara M. WeisSushil KumarLisa M. CoussensDaniel G. AndersonClark C. ChenDavid A. ChereshSudarshan AnandNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
description	The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.
format	article
author	RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand
author_facet	RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand
author_sort	RaeAnna Wilson
title	MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
title_short	MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
title_full	MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
title_fullStr	MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
title_full_unstemmed	MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
title_sort	microrna regulation of endothelial trex1 reprograms the tumour microenvironment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a01c9f15bea14236bb83264f01ebc409
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MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

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