The associations between serum trace elements and bone mineral density in children under 3 years of age

Abstract We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square...

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Autores principales:	Ziyi Wu, Yuhao Yuan, Jian Tian, Feng Long, Wei Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a01db66deb364449b30ae03dd8dd90d0
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spelling	oai:doaj.org-article:a01db66deb364449b30ae03dd8dd90d02021-12-02T13:51:05ZThe associations between serum trace elements and bone mineral density in children under 3 years of age10.1038/s41598-021-81501-32045-2322https://doaj.org/article/a01db66deb364449b30ae03dd8dd90d02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81501-3https://doaj.org/toc/2045-2322Abstract We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determine the associations of age and serum trace elements with BMD. Multivariable logistic regression analysis was used to test the correlation of five serum trace elements with BMD after adjustments for potential confounding factors in children under 3 years of age. Significant associations between age and four serum trace elements and BMD were found. Compared to the group with the lowest serum levels detected, the adjusted odds ratio (OR) for the incidence of normal bone mineral density in the third magnesium concentration tertile, the third iron concentration tertile, the fifth copper concentration quintile, the third zinc concentration quintile, and the fifth zinc concentration quintile were 1.30 (95% confidence interval (CI) 1.02–1.67), 1.43 (95% CI 1.11–1.84), 1.42 (95% CI 1.04–1.94), 1.46 (95% CI 1.05–2.04), and 1.48 (95% CI 1.06–2.06), respectively. However, there was no significant correlation between serum lead level and BMD in this study. Age and serum magnesium, iron, copper, and zinc levels are positively associated with BMD in children under 3 years old.Ziyi WuYuhao YuanJian TianFeng LongWei LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ziyi Wu Yuhao Yuan Jian Tian Feng Long Wei Luo The associations between serum trace elements and bone mineral density in children under 3 years of age
description	Abstract We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determine the associations of age and serum trace elements with BMD. Multivariable logistic regression analysis was used to test the correlation of five serum trace elements with BMD after adjustments for potential confounding factors in children under 3 years of age. Significant associations between age and four serum trace elements and BMD were found. Compared to the group with the lowest serum levels detected, the adjusted odds ratio (OR) for the incidence of normal bone mineral density in the third magnesium concentration tertile, the third iron concentration tertile, the fifth copper concentration quintile, the third zinc concentration quintile, and the fifth zinc concentration quintile were 1.30 (95% confidence interval (CI) 1.02–1.67), 1.43 (95% CI 1.11–1.84), 1.42 (95% CI 1.04–1.94), 1.46 (95% CI 1.05–2.04), and 1.48 (95% CI 1.06–2.06), respectively. However, there was no significant correlation between serum lead level and BMD in this study. Age and serum magnesium, iron, copper, and zinc levels are positively associated with BMD in children under 3 years old.
format	article
author	Ziyi Wu Yuhao Yuan Jian Tian Feng Long Wei Luo
author_facet	Ziyi Wu Yuhao Yuan Jian Tian Feng Long Wei Luo
author_sort	Ziyi Wu
title	The associations between serum trace elements and bone mineral density in children under 3 years of age
title_short	The associations between serum trace elements and bone mineral density in children under 3 years of age
title_full	The associations between serum trace elements and bone mineral density in children under 3 years of age
title_fullStr	The associations between serum trace elements and bone mineral density in children under 3 years of age
title_full_unstemmed	The associations between serum trace elements and bone mineral density in children under 3 years of age
title_sort	associations between serum trace elements and bone mineral density in children under 3 years of age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a01db66deb364449b30ae03dd8dd90d0
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The associations between serum trace elements and bone mineral density in children under 3 years of age

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