Thymus in children with type 1 diabetes mellitus
Aim. To determine size structure and blood circulation of thymus in children with type 1 diabetes mellitus (DM1) by ultrasound.We have undertaken an ultrasonic study of thymus in 62 children aged 4-17 years with DM1 to determine its size, structure and bloodcirculation. Results.It was shown for the...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | article |
| Lenguaje: | EN RU |
| Publicado: |
Endocrinology Research Centre
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a01e4b0b81254881a157d38de7f6a1ca |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a01e4b0b81254881a157d38de7f6a1ca |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a01e4b0b81254881a157d38de7f6a1ca2021-11-14T09:00:16ZThymus in children with type 1 diabetes mellitus2072-03512072-037810.14341/2072-0351-5639https://doaj.org/article/a01e4b0b81254881a157d38de7f6a1ca2011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5639https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To determine size structure and blood circulation of thymus in children with type 1 diabetes mellitus (DM1) by ultrasound.We have undertaken an ultrasonic study of thymus in 62 children aged 4-17 years with DM1 to determine its size, structure and bloodcirculation. Results.It was shown for the first time that the thymus of DM1 children is enlarged and fairly well visualized unlike that in agematchedhealthy patients in whom it is much smaller due to age-related involution and substitution of the thymic tissue by adipose one. Colorand energetic Doppler mapping showed perfect vascularization of the thymus in DM1 children compared with healthy patients in whom thismethod failed to map blood flow due to the substitution of the original thymic tissue by parenchymal and adipose tissues and dropout of bloodvessels. Conclusion the study for the first time gave evidence that thymus, the main immunogenic organ (conductor of the immune system),undergoes age-specific changes of size and structure whereas DM1 of autoimmune etiology precludes its involution.Olga Borisovna SirotinaEndocrinology Research Centrearticlediabetes mellitus type 1thymuschildrenultrasonic studyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 75-77 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN RU |
| topic |
diabetes mellitus type 1 thymus children ultrasonic study Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
diabetes mellitus type 1 thymus children ultrasonic study Nutritional diseases. Deficiency diseases RC620-627 Olga Borisovna Sirotina Thymus in children with type 1 diabetes mellitus |
| description |
Aim. To determine size structure and blood circulation of thymus in children with type 1 diabetes mellitus (DM1) by ultrasound.We have undertaken an ultrasonic study of thymus in 62 children aged 4-17 years with DM1 to determine its size, structure and bloodcirculation. Results.It was shown for the first time that the thymus of DM1 children is enlarged and fairly well visualized unlike that in agematchedhealthy patients in whom it is much smaller due to age-related involution and substitution of the thymic tissue by adipose one. Colorand energetic Doppler mapping showed perfect vascularization of the thymus in DM1 children compared with healthy patients in whom thismethod failed to map blood flow due to the substitution of the original thymic tissue by parenchymal and adipose tissues and dropout of bloodvessels. Conclusion the study for the first time gave evidence that thymus, the main immunogenic organ (conductor of the immune system),undergoes age-specific changes of size and structure whereas DM1 of autoimmune etiology precludes its involution. |
| format |
article |
| author |
Olga Borisovna Sirotina |
| author_facet |
Olga Borisovna Sirotina |
| author_sort |
Olga Borisovna Sirotina |
| title |
Thymus in children with type 1 diabetes mellitus |
| title_short |
Thymus in children with type 1 diabetes mellitus |
| title_full |
Thymus in children with type 1 diabetes mellitus |
| title_fullStr |
Thymus in children with type 1 diabetes mellitus |
| title_full_unstemmed |
Thymus in children with type 1 diabetes mellitus |
| title_sort |
thymus in children with type 1 diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2011 |
| url |
https://doaj.org/article/a01e4b0b81254881a157d38de7f6a1ca |
| work_keys_str_mv |
AT olgaborisovnasirotina thymusinchildrenwithtype1diabetesmellitus |
| _version_ |
1718429599002525696 |