Migraine in patients with rheumatoid arthritis and its relation to disease activity

Abstract Background The comorbidity between rheumatoid arthritis (RA) and migraine is complex and not completely understood. Objective This study aimed to evaluate migraine frequency in patients with RA and its relation to disease activity. Methods A cross-sectional study was carried out on 210 cons...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hassan Abd-Elaty El-Sonbaty, Carmen Ali Zarad, Mohamed Rezk Mohamed, Ali Ahmed Abou Elmaaty
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Migraine Rheumatoid arthritis Disease activity DAS-28 MHAQ Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a01f1743a3cc4a1aaa9eaf323cdc7add
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a01f1743a3cc4a1aaa9eaf323cdc7add
record_format	dspace
spelling	oai:doaj.org-article:a01f1743a3cc4a1aaa9eaf323cdc7add2021-11-08T10:44:32ZMigraine in patients with rheumatoid arthritis and its relation to disease activity10.1186/s41983-021-00406-01687-8329https://doaj.org/article/a01f1743a3cc4a1aaa9eaf323cdc7add2021-11-01T00:00:00Zhttps://doi.org/10.1186/s41983-021-00406-0https://doaj.org/toc/1687-8329Abstract Background The comorbidity between rheumatoid arthritis (RA) and migraine is complex and not completely understood. Objective This study aimed to evaluate migraine frequency in patients with RA and its relation to disease activity. Methods A cross-sectional study was carried out on 210 consecutive RA Egyptian patients fulfilling the 2010 EULAR/ACR criteria (joint distribution, serology, symptom duration and acute phase reaction). Results Prevalence of migraine in RA was 28.2%. Disease activity, fibromyalgia and functional losses were significantly higher in migraine group with RA versus non-migraine group (P < 0.001). Disease Activity Score (DAS-28) was independently significant predictor as increasing DAS-28 score was associated with an increased likelihood of exhibiting migraine (5.5-times higher odds per one-unit increase in DAS-28 score). Prevalence of brain MRI white matter hyper-intensities (WMHs) in RA with migraine was 54.8%. WMHs were significantly higher in migraine patients with aura than migraine patients without aura, especially in older patients, longer migraine duration, longer rheumatoid duration and elevated ESR (p < 0.047, p < 0.034, P < 0.004, P < 0.015 and P < 0.22, respectively). Conclusions Migraine is highly frequent in RA patients, especially migraine with aura. The presence of rheumatoid activity, fibromyalgia and secondary Sjogren’s syndrome, elevated ESR and CRP are associated with functional losses in RA patients with migraine, especially migraine with aura. MR imaging of brain is a mandatory tool for detection of white matter hyper-intensities in RA patients with migraine, especially migraine with aura.Hassan Abd-Elaty El-SonbatyCarmen Ali ZaradMohamed Rezk MohamedAli Ahmed Abou ElmaatySpringerOpenarticleMigraineRheumatoid arthritisDisease activityDAS-28MHAQNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 57, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Migraine Rheumatoid arthritis Disease activity DAS-28 MHAQ Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Migraine Rheumatoid arthritis Disease activity DAS-28 MHAQ Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hassan Abd-Elaty El-Sonbaty Carmen Ali Zarad Mohamed Rezk Mohamed Ali Ahmed Abou Elmaaty Migraine in patients with rheumatoid arthritis and its relation to disease activity
description	Abstract Background The comorbidity between rheumatoid arthritis (RA) and migraine is complex and not completely understood. Objective This study aimed to evaluate migraine frequency in patients with RA and its relation to disease activity. Methods A cross-sectional study was carried out on 210 consecutive RA Egyptian patients fulfilling the 2010 EULAR/ACR criteria (joint distribution, serology, symptom duration and acute phase reaction). Results Prevalence of migraine in RA was 28.2%. Disease activity, fibromyalgia and functional losses were significantly higher in migraine group with RA versus non-migraine group (P < 0.001). Disease Activity Score (DAS-28) was independently significant predictor as increasing DAS-28 score was associated with an increased likelihood of exhibiting migraine (5.5-times higher odds per one-unit increase in DAS-28 score). Prevalence of brain MRI white matter hyper-intensities (WMHs) in RA with migraine was 54.8%. WMHs were significantly higher in migraine patients with aura than migraine patients without aura, especially in older patients, longer migraine duration, longer rheumatoid duration and elevated ESR (p < 0.047, p < 0.034, P < 0.004, P < 0.015 and P < 0.22, respectively). Conclusions Migraine is highly frequent in RA patients, especially migraine with aura. The presence of rheumatoid activity, fibromyalgia and secondary Sjogren’s syndrome, elevated ESR and CRP are associated with functional losses in RA patients with migraine, especially migraine with aura. MR imaging of brain is a mandatory tool for detection of white matter hyper-intensities in RA patients with migraine, especially migraine with aura.
format	article
author	Hassan Abd-Elaty El-Sonbaty Carmen Ali Zarad Mohamed Rezk Mohamed Ali Ahmed Abou Elmaaty
author_facet	Hassan Abd-Elaty El-Sonbaty Carmen Ali Zarad Mohamed Rezk Mohamed Ali Ahmed Abou Elmaaty
author_sort	Hassan Abd-Elaty El-Sonbaty
title	Migraine in patients with rheumatoid arthritis and its relation to disease activity
title_short	Migraine in patients with rheumatoid arthritis and its relation to disease activity
title_full	Migraine in patients with rheumatoid arthritis and its relation to disease activity
title_fullStr	Migraine in patients with rheumatoid arthritis and its relation to disease activity
title_full_unstemmed	Migraine in patients with rheumatoid arthritis and its relation to disease activity
title_sort	migraine in patients with rheumatoid arthritis and its relation to disease activity
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/a01f1743a3cc4a1aaa9eaf323cdc7add
work_keys_str_mv	AT hassanabdelatyelsonbaty migraineinpatientswithrheumatoidarthritisanditsrelationtodiseaseactivity AT carmenalizarad migraineinpatientswithrheumatoidarthritisanditsrelationtodiseaseactivity AT mohamedrezkmohamed migraineinpatientswithrheumatoidarthritisanditsrelationtodiseaseactivity AT aliahmedabouelmaaty migraineinpatientswithrheumatoidarthritisanditsrelationtodiseaseactivity
_version_	1718442646845784064

Migraine in patients with rheumatoid arthritis and its relation to disease activity

Ejemplares similares