Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor

Abstract This article presents the construction of a multimodality platform that can be used for efficient destruction of brain tumor by a combination of photodynamic and sonodynamic therapy. For in vivo studies, U87 patient-derived xenograft tumors were implanted subcutaneously in SCID mice. For th...

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Autores principales:	Ballav M. Borah, Joseph Cacaccio, Farukh A. Durrani, Wiam Bshara, Steven G. Turowski, Joseph A. Spernyak, Ravindra K. Pandey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a02153428d9443d0abc09e951259cca0
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spelling	oai:doaj.org-article:a02153428d9443d0abc09e951259cca02021-12-02T16:18:05ZSonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor10.1038/s41598-020-78153-02045-2322https://doaj.org/article/a02153428d9443d0abc09e951259cca02020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78153-0https://doaj.org/toc/2045-2322Abstract This article presents the construction of a multimodality platform that can be used for efficient destruction of brain tumor by a combination of photodynamic and sonodynamic therapy. For in vivo studies, U87 patient-derived xenograft tumors were implanted subcutaneously in SCID mice. For the first time, it has been shown that the cell-death mechanism by both treatment modalities follows two different pathways. For example, exposing the U87 cells after 24 h incubation with HPPH [3-(1′-hexyloxy)ethyl-3-devinyl-pyropheophorbide-a) by ultrasound participate in an electron-transfer process with the surrounding biological substrates to form radicals and radical ions (Type I reaction); whereas in photodynamic therapy, the tumor destruction is mainly caused by highly reactive singlet oxygen (Type II reaction). The combination of photodynamic therapy and sonodynamic therapy both in vitro and in vivo have shown an improved cell kill/tumor response, that could be attributed to an additive and/or synergetic effect(s). Our results also indicate that the delivery of the HPPH to tumors can further be enhanced by using cationic polyacrylamide nanoparticles as a delivery vehicle. Exposing the nano-formulation with ultrasound also triggered the release of photosensitizer. The combination of photodynamic therapy and sonodynamic therapy strongly affects tumor vasculature as determined by dynamic contrast enhanced imaging using HSA-Gd(III)DTPA.Ballav M. BorahJoseph CacaccioFarukh A. DurraniWiam BsharaSteven G. TurowskiJoseph A. SpernyakRavindra K. PandeyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ballav M. Borah Joseph Cacaccio Farukh A. Durrani Wiam Bshara Steven G. Turowski Joseph A. Spernyak Ravindra K. Pandey Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
description	Abstract This article presents the construction of a multimodality platform that can be used for efficient destruction of brain tumor by a combination of photodynamic and sonodynamic therapy. For in vivo studies, U87 patient-derived xenograft tumors were implanted subcutaneously in SCID mice. For the first time, it has been shown that the cell-death mechanism by both treatment modalities follows two different pathways. For example, exposing the U87 cells after 24 h incubation with HPPH [3-(1′-hexyloxy)ethyl-3-devinyl-pyropheophorbide-a) by ultrasound participate in an electron-transfer process with the surrounding biological substrates to form radicals and radical ions (Type I reaction); whereas in photodynamic therapy, the tumor destruction is mainly caused by highly reactive singlet oxygen (Type II reaction). The combination of photodynamic therapy and sonodynamic therapy both in vitro and in vivo have shown an improved cell kill/tumor response, that could be attributed to an additive and/or synergetic effect(s). Our results also indicate that the delivery of the HPPH to tumors can further be enhanced by using cationic polyacrylamide nanoparticles as a delivery vehicle. Exposing the nano-formulation with ultrasound also triggered the release of photosensitizer. The combination of photodynamic therapy and sonodynamic therapy strongly affects tumor vasculature as determined by dynamic contrast enhanced imaging using HSA-Gd(III)DTPA.
format	article
author	Ballav M. Borah Joseph Cacaccio Farukh A. Durrani Wiam Bshara Steven G. Turowski Joseph A. Spernyak Ravindra K. Pandey
author_facet	Ballav M. Borah Joseph Cacaccio Farukh A. Durrani Wiam Bshara Steven G. Turowski Joseph A. Spernyak Ravindra K. Pandey
author_sort	Ballav M. Borah
title	Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
title_short	Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
title_full	Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
title_fullStr	Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
title_full_unstemmed	Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
title_sort	sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a02153428d9443d0abc09e951259cca0
work_keys_str_mv	AT ballavmborah sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT josephcacaccio sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT farukhadurrani sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT wiambshara sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT stevengturowski sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT josephaspernyak sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor AT ravindrakpandey sonodynamictherapyincombinationwithphotodynamictherapyshowsenhancedlongtermcureofbraintumor
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Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor

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