Managing dyslipidemia in HIV/AIDS patients: challenges and solutions

Nazik Elmalaika OS Husain,1 Mohamed H Ahmed21Department of Pathology, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan; 2Department of Medicine, Milton Keynes Hospital, NHS Foundation Trust, Milton Keynes, UK Abstract: Human immunodeficiency virus (HIV) is a ch...

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Autores principales:	Husain NE, Ahmed MH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a021ecb9a8b2401494e5175503e00ff8
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spelling	oai:doaj.org-article:a021ecb9a8b2401494e5175503e00ff82021-12-02T08:12:03ZManaging dyslipidemia in HIV/AIDS patients: challenges and solutions1179-1373https://doaj.org/article/a021ecb9a8b2401494e5175503e00ff82014-12-01T00:00:00Zhttp://www.dovepress.com/managing-dyslipidemia-in-hivaids-patients-challenges-and-solutions-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373 Nazik Elmalaika OS Husain,1 Mohamed H Ahmed21Department of Pathology, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan; 2Department of Medicine, Milton Keynes Hospital, NHS Foundation Trust, Milton Keynes, UK Abstract: Human immunodeficiency virus (HIV) is a chronic disease associated with dyslipidemia and insulin resistance. In addition, the administration of combination antiretroviral therapy is associated with an increase in the incidence of metabolic risk factors (insulin resistance, lipoatrophy, dyslipidemia, and abnormalities of fat distribution in HIV patients). HIV dyslipidemia is a common problem, and associated with an increase in incidence of cardiovascular disease. Further challenges in the management of HIV dyslipidemia are the presence of diabetes and metabolic syndrome, nonalcoholic fatty liver disease, hypothyroidism, chronic kidney disease, the risk of diabetes associated with statin administration, age and ethnicity, and early menopause in females. Dyslipidemia in patients with HIV is different from the normal population, due to the fact that HIV increases insulin resistance and HIV treatment not only may induce dyslipidemia but also may interact with lipid-lowering medication. The use of all statins (apart from simvastatin and lovastatin) is safe and effective in HIV dyslipidemia, and the addition of ezetimibe, fenofibrate, fish oil, and niacin can be used in statin-unresponsive HIV dyslipidemia. The management of dyslipidemia and cardiovascular disease risks associated with HIV is complex, and a certain number of patients may require management in specialist clinics run by specialist physicians in lipid disorders. Future research is needed to address best strategies in the management of hyperlipidemia with HIV infection. Keywords: HIV, dylipidaemia, cardiovascular disease, insulin resistance, fatty liver, lipid lowering medicationHusain NEAhmed MHDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2015, Iss default, Pp 1-10 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Husain NE Ahmed MH Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
description	Nazik Elmalaika OS Husain,1 Mohamed H Ahmed21Department of Pathology, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan; 2Department of Medicine, Milton Keynes Hospital, NHS Foundation Trust, Milton Keynes, UK Abstract: Human immunodeficiency virus (HIV) is a chronic disease associated with dyslipidemia and insulin resistance. In addition, the administration of combination antiretroviral therapy is associated with an increase in the incidence of metabolic risk factors (insulin resistance, lipoatrophy, dyslipidemia, and abnormalities of fat distribution in HIV patients). HIV dyslipidemia is a common problem, and associated with an increase in incidence of cardiovascular disease. Further challenges in the management of HIV dyslipidemia are the presence of diabetes and metabolic syndrome, nonalcoholic fatty liver disease, hypothyroidism, chronic kidney disease, the risk of diabetes associated with statin administration, age and ethnicity, and early menopause in females. Dyslipidemia in patients with HIV is different from the normal population, due to the fact that HIV increases insulin resistance and HIV treatment not only may induce dyslipidemia but also may interact with lipid-lowering medication. The use of all statins (apart from simvastatin and lovastatin) is safe and effective in HIV dyslipidemia, and the addition of ezetimibe, fenofibrate, fish oil, and niacin can be used in statin-unresponsive HIV dyslipidemia. The management of dyslipidemia and cardiovascular disease risks associated with HIV is complex, and a certain number of patients may require management in specialist clinics run by specialist physicians in lipid disorders. Future research is needed to address best strategies in the management of hyperlipidemia with HIV infection. Keywords: HIV, dylipidaemia, cardiovascular disease, insulin resistance, fatty liver, lipid lowering medication
format	article
author	Husain NE Ahmed MH
author_facet	Husain NE Ahmed MH
author_sort	Husain NE
title	Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
title_short	Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
title_full	Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
title_fullStr	Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
title_full_unstemmed	Managing dyslipidemia in HIV/AIDS patients: challenges and solutions
title_sort	managing dyslipidemia in hiv/aids patients: challenges and solutions
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a021ecb9a8b2401494e5175503e00ff8
work_keys_str_mv	AT husainne managingdyslipidemiainhivaidspatientschallengesandsolutions AT ahmedmh managingdyslipidemiainhivaidspatientschallengesandsolutions
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Managing dyslipidemia in HIV/AIDS patients: challenges and solutions

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