Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.

<h4>Background</h4>The increased mortality in HCV-infected individuals partly stems from viral damage to the liver and partly from risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the general population. We also addressed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lars Haukali Omland, Peer Brehm Christensen, Henrik Krarup, Peter Jepsen, Nina Weis, Henrik Toft Sørensen, Niels Obel, DANVIR Cohort Study
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a02b53eb3d3a47378b8c1e39390fcb11
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a02b53eb3d3a47378b8c1e39390fcb11
record_format	dspace
spelling	oai:doaj.org-article:a02b53eb3d3a47378b8c1e39390fcb112021-11-18T06:50:04ZMortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.1932-620310.1371/journal.pone.0022476https://doaj.org/article/a02b53eb3d3a47378b8c1e39390fcb112011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789259/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The increased mortality in HCV-infected individuals partly stems from viral damage to the liver and partly from risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the general population. We also addressed the question whether prognosis differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity.<h4>Methodology/principal findings</h4>Patients with cleared HCV-infection were categorized into one of 8 groups according to age (20-39 years or 40-69 years) and patient characteristics (no substance abuse/no comorbidity; substance abuse/no comorbidity; no substance abuse/comorbidity; and substance abuse/comorbidity). For each patient, 4 age- and gender-matched individuals without substance abuse or comorbidity were selected from the general population, comprising a total of 8 comparison cohorts. We analyzed 10-year survival and used stratified Cox Regression analysis to compute mortality rate ratios (MRRs), comparing mortality between the 8 patient groups and the comparison cohorts, adjusting for personal income. Among patients without substance abuse or comorbidity, those aged 40-69 years had the same mortality as the comparison cohort (10-year survival: 95% (95% confidence interval [CI]: 93%-97%), MRR: 1.3 (95% CI: 0.8-2.3)), whereas those aged 20-39 years had higher mortality than the comparison cohort (10-year survival: 93% versus 99%, MRR: 5.7 (95% CI: 2.3-14.0). For both age categories, substance abuse and comorbidity decreased survival and increased MRRs. Patients aged 40-69 years with substance abuse and comorbidity suffered from substantial mortality (MRR: 12.5 (95% CI: 5.1-30.6)).<h4>Conclusions</h4>Mortality in patients aged 40-69 years with cleared HCV-infection is comparable to individuals without HCV, provided they have no substance abuse or comorbidity. Any substance abuse and/or comorbidity not captured in the registries used for our study could explain the increased mortality in patients aged 20-39 years without documented substance abuse or comorbidity.Lars Haukali OmlandPeer Brehm ChristensenHenrik KrarupPeter JepsenNina WeisHenrik Toft SørensenNiels ObelDANVIR Cohort StudyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22476 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lars Haukali Omland Peer Brehm Christensen Henrik Krarup Peter Jepsen Nina Weis Henrik Toft Sørensen Niels Obel DANVIR Cohort Study Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
description	<h4>Background</h4>The increased mortality in HCV-infected individuals partly stems from viral damage to the liver and partly from risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the general population. We also addressed the question whether prognosis differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity.<h4>Methodology/principal findings</h4>Patients with cleared HCV-infection were categorized into one of 8 groups according to age (20-39 years or 40-69 years) and patient characteristics (no substance abuse/no comorbidity; substance abuse/no comorbidity; no substance abuse/comorbidity; and substance abuse/comorbidity). For each patient, 4 age- and gender-matched individuals without substance abuse or comorbidity were selected from the general population, comprising a total of 8 comparison cohorts. We analyzed 10-year survival and used stratified Cox Regression analysis to compute mortality rate ratios (MRRs), comparing mortality between the 8 patient groups and the comparison cohorts, adjusting for personal income. Among patients without substance abuse or comorbidity, those aged 40-69 years had the same mortality as the comparison cohort (10-year survival: 95% (95% confidence interval [CI]: 93%-97%), MRR: 1.3 (95% CI: 0.8-2.3)), whereas those aged 20-39 years had higher mortality than the comparison cohort (10-year survival: 93% versus 99%, MRR: 5.7 (95% CI: 2.3-14.0). For both age categories, substance abuse and comorbidity decreased survival and increased MRRs. Patients aged 40-69 years with substance abuse and comorbidity suffered from substantial mortality (MRR: 12.5 (95% CI: 5.1-30.6)).<h4>Conclusions</h4>Mortality in patients aged 40-69 years with cleared HCV-infection is comparable to individuals without HCV, provided they have no substance abuse or comorbidity. Any substance abuse and/or comorbidity not captured in the registries used for our study could explain the increased mortality in patients aged 20-39 years without documented substance abuse or comorbidity.
format	article
author	Lars Haukali Omland Peer Brehm Christensen Henrik Krarup Peter Jepsen Nina Weis Henrik Toft Sørensen Niels Obel DANVIR Cohort Study
author_facet	Lars Haukali Omland Peer Brehm Christensen Henrik Krarup Peter Jepsen Nina Weis Henrik Toft Sørensen Niels Obel DANVIR Cohort Study
author_sort	Lars Haukali Omland
title	Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
title_short	Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
title_full	Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
title_fullStr	Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
title_full_unstemmed	Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.
title_sort	mortality among patients with cleared hepatitis c virus infection compared to the general population: a danish nationwide cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a02b53eb3d3a47378b8c1e39390fcb11
work_keys_str_mv	AT larshaukaliomland mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT peerbrehmchristensen mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT henrikkrarup mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT peterjepsen mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT ninaweis mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT henriktoftsørensen mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT nielsobel mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy AT danvircohortstudy mortalityamongpatientswithclearedhepatitiscvirusinfectioncomparedtothegeneralpopulationadanishnationwidecohortstudy
_version_	1718424370057052160

Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study.

Ejemplares similares