Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.

Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We investigated the effect of Rac-1 and Rho kina...

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Autores principales: Andrea Babelova, Felix Jansen, Kerstin Sander, Matthias Löhn, Liliana Schäfer, Christian Fork, Hartmut Ruetten, Oliver Plettenburg, Holger Stark, Christoph Daniel, Kerstin Amann, Hermann Pavenstädt, Oliver Jung, Ralf P Brandes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a03051003e6a4e74ada3d1db6d87b6ce
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