PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augments the tumorigenic capacity of a dominant-negative...

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Autores principales:	Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sven Becker, Klaus Strebhardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc
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spelling	oai:doaj.org-article:a03432a0fac04ac49c63a7cf0e5451dc2021-12-02T14:40:55ZPLK1 has tumor-suppressive potential in APC-truncated colon cancer cells10.1038/s41467-018-03494-42041-1723https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03494-4https://doaj.org/toc/2041-1723The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augments the tumorigenic capacity of a dominant-negative ∆APC mutant by increasing polyploidy and cell division.Monika RaabMourad SanhajiYves MatthessAlbrecht HörlinIoana LorenzChristina DötschNils HabbeOliver WaidmannElisabeth Kurunci-CsacskoRon FiresteinSven BeckerKlaus StrebhardtNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Monika Raab Mourad Sanhaji Yves Matthess Albrecht Hörlin Ioana Lorenz Christina Dötsch Nils Habbe Oliver Waidmann Elisabeth Kurunci-Csacsko Ron Firestein Sven Becker Klaus Strebhardt PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
description	The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augments the tumorigenic capacity of a dominant-negative ∆APC mutant by increasing polyploidy and cell division.
format	article
author	Monika Raab Mourad Sanhaji Yves Matthess Albrecht Hörlin Ioana Lorenz Christina Dötsch Nils Habbe Oliver Waidmann Elisabeth Kurunci-Csacsko Ron Firestein Sven Becker Klaus Strebhardt
author_facet	Monika Raab Mourad Sanhaji Yves Matthess Albrecht Hörlin Ioana Lorenz Christina Dötsch Nils Habbe Oliver Waidmann Elisabeth Kurunci-Csacsko Ron Firestein Sven Becker Klaus Strebhardt
author_sort	Monika Raab
title	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
title_short	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
title_full	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
title_fullStr	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
title_full_unstemmed	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
title_sort	plk1 has tumor-suppressive potential in apc-truncated colon cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc
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PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

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