Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs

Abstract Foundational hypotheses addressing plant–insect codiversification and plant defense theory typically assume a macroevolutionary pattern whereby closely related plants have similar chemical profiles. However, numerous studies have documented variation in the degree of phytochemical trait lab...

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Autores principales:	Kathryn A. Uckele, Joshua P. Jahner, Eric J. Tepe, Lora A. Richards, Lee A. Dyer, Kaitlin M. Ochsenrider, Casey S. Philbin, Massuo J. Kato, Lydia F. Yamaguchi, Matthew L. Forister, Angela M. Smilanich, Craig D. Dodson, Christopher S. Jeffrey, Thomas L. Parchman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a034e4ce05c04cbe807bccc27665887f
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spelling	oai:doaj.org-article:a034e4ce05c04cbe807bccc27665887f2021-12-02T18:53:14ZPhytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs10.1038/s41598-021-96431-32045-2322https://doaj.org/article/a034e4ce05c04cbe807bccc27665887f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96431-3https://doaj.org/toc/2045-2322Abstract Foundational hypotheses addressing plant–insect codiversification and plant defense theory typically assume a macroevolutionary pattern whereby closely related plants have similar chemical profiles. However, numerous studies have documented variation in the degree of phytochemical trait lability, raising the possibility that phytochemical evolution is more nuanced than initially assumed. We utilize proton nuclear magnetic resonance (1H NMR) data, chemical classification, and double digest restriction-site associated DNA sequencing (ddRADseq) to resolve evolutionary relationships and characterize the evolution of secondary chemistry in the Neotropical plant clade Radula (Piper; Piperaceae). Sequencing data substantially improved phylogenetic resolution relative to past studies, and spectroscopic characterization revealed the presence of 35 metabolite classes. Metabolite classes displayed phylogenetic signal, whereas the crude 1H NMR spectra featured little evidence of phylogenetic signal in multivariate tests of chemical resonances. Evolutionary correlations were detected in two pairs of compound classes (flavonoids with chalcones; p-alkenyl phenols with kavalactones), where the gain or loss of a class was dependent on the other’s state. Overall, the evolution of secondary chemistry in Radula is characterized by strong phylogenetic signal of traditional compound classes and weak phylogenetic signal of specialized chemical motifs, consistent with both classic evolutionary hypotheses and recent examinations of phytochemical evolution in young lineages.Kathryn A. UckeleJoshua P. JahnerEric J. TepeLora A. RichardsLee A. DyerKaitlin M. OchsenriderCasey S. PhilbinMassuo J. KatoLydia F. YamaguchiMatthew L. ForisterAngela M. SmilanichCraig D. DodsonChristopher S. JeffreyThomas L. ParchmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kathryn A. Uckele Joshua P. Jahner Eric J. Tepe Lora A. Richards Lee A. Dyer Kaitlin M. Ochsenrider Casey S. Philbin Massuo J. Kato Lydia F. Yamaguchi Matthew L. Forister Angela M. Smilanich Craig D. Dodson Christopher S. Jeffrey Thomas L. Parchman Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
description	Abstract Foundational hypotheses addressing plant–insect codiversification and plant defense theory typically assume a macroevolutionary pattern whereby closely related plants have similar chemical profiles. However, numerous studies have documented variation in the degree of phytochemical trait lability, raising the possibility that phytochemical evolution is more nuanced than initially assumed. We utilize proton nuclear magnetic resonance (1H NMR) data, chemical classification, and double digest restriction-site associated DNA sequencing (ddRADseq) to resolve evolutionary relationships and characterize the evolution of secondary chemistry in the Neotropical plant clade Radula (Piper; Piperaceae). Sequencing data substantially improved phylogenetic resolution relative to past studies, and spectroscopic characterization revealed the presence of 35 metabolite classes. Metabolite classes displayed phylogenetic signal, whereas the crude 1H NMR spectra featured little evidence of phylogenetic signal in multivariate tests of chemical resonances. Evolutionary correlations were detected in two pairs of compound classes (flavonoids with chalcones; p-alkenyl phenols with kavalactones), where the gain or loss of a class was dependent on the other’s state. Overall, the evolution of secondary chemistry in Radula is characterized by strong phylogenetic signal of traditional compound classes and weak phylogenetic signal of specialized chemical motifs, consistent with both classic evolutionary hypotheses and recent examinations of phytochemical evolution in young lineages.
format	article
author	Kathryn A. Uckele Joshua P. Jahner Eric J. Tepe Lora A. Richards Lee A. Dyer Kaitlin M. Ochsenrider Casey S. Philbin Massuo J. Kato Lydia F. Yamaguchi Matthew L. Forister Angela M. Smilanich Craig D. Dodson Christopher S. Jeffrey Thomas L. Parchman
author_facet	Kathryn A. Uckele Joshua P. Jahner Eric J. Tepe Lora A. Richards Lee A. Dyer Kaitlin M. Ochsenrider Casey S. Philbin Massuo J. Kato Lydia F. Yamaguchi Matthew L. Forister Angela M. Smilanich Craig D. Dodson Christopher S. Jeffrey Thomas L. Parchman
author_sort	Kathryn A. Uckele
title	Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
title_short	Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
title_full	Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
title_fullStr	Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
title_full_unstemmed	Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
title_sort	phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a034e4ce05c04cbe807bccc27665887f
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_version_	1718377344490536960

Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs

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