Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis

Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the...

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Autores principales:	Madina Sarsenova, Assel Issabekova, Saule Abisheva, Kristina Rutskaya-Moroshan, Vyacheslav Ogay, Arman Saparov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stem cells rheumatoid arthritis inflammation cell therapy cell preconditioning immunomodulation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a039e76fc8f845f99656095a86da1705
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spelling	oai:doaj.org-article:a039e76fc8f845f99656095a86da17052021-11-11T17:04:22ZMesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis10.3390/ijms2221115921422-00671661-6596https://doaj.org/article/a039e76fc8f845f99656095a86da17052021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11592https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the treatment of autoimmune diseases, and can serve as a promising tool in stem cell-based therapy. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that deteriorates quality and function of the synovium membrane, resulting in chronic inflammation, pain and progressive cartilage and bone destruction. The mechanism of RA pathogenesis is associated with dysregulation of innate and adaptive immunity. Current conventional treatments by steroid drugs, antirheumatic drugs and biological agents are being applied in clinical practice. However, long-term use of these drugs causes side effects, and some RA patients may acquire resistance to these drugs. In this regard, recently investigated MSC-based therapy is considered as a promising approach in RA treatment. In this study, we review conventional and modern treatment approaches, such as MSC-based therapy through the understanding of the link between MSCs and the innate and adaptive immune systems. Moreover, we discuss recent achievements in preclinical and clinical studies as well as various strategies for the enhancement of MSC immunoregulatory properties.Madina SarsenovaAssel IssabekovaSaule AbishevaKristina Rutskaya-MoroshanVyacheslav OgayArman SaparovMDPI AGarticlemesenchymal stem cellsrheumatoid arthritisinflammationcell therapycell preconditioningimmunomodulationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11592, p 11592 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells rheumatoid arthritis inflammation cell therapy cell preconditioning immunomodulation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mesenchymal stem cells rheumatoid arthritis inflammation cell therapy cell preconditioning immunomodulation Biology (General) QH301-705.5 Chemistry QD1-999 Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
description	Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the treatment of autoimmune diseases, and can serve as a promising tool in stem cell-based therapy. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that deteriorates quality and function of the synovium membrane, resulting in chronic inflammation, pain and progressive cartilage and bone destruction. The mechanism of RA pathogenesis is associated with dysregulation of innate and adaptive immunity. Current conventional treatments by steroid drugs, antirheumatic drugs and biological agents are being applied in clinical practice. However, long-term use of these drugs causes side effects, and some RA patients may acquire resistance to these drugs. In this regard, recently investigated MSC-based therapy is considered as a promising approach in RA treatment. In this study, we review conventional and modern treatment approaches, such as MSC-based therapy through the understanding of the link between MSCs and the innate and adaptive immune systems. Moreover, we discuss recent achievements in preclinical and clinical studies as well as various strategies for the enhancement of MSC immunoregulatory properties.
format	article
author	Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov
author_facet	Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov
author_sort	Madina Sarsenova
title	Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
title_short	Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
title_full	Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
title_fullStr	Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
title_full_unstemmed	Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
title_sort	mesenchymal stem cell-based therapy for rheumatoid arthritis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a039e76fc8f845f99656095a86da1705
work_keys_str_mv	AT madinasarsenova mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT asselissabekova mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT sauleabisheva mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT kristinarutskayamoroshan mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT vyacheslavogay mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT armansaparov mesenchymalstemcellbasedtherapyforrheumatoidarthritis
_version_	1718432192693010432

Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis

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