Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study

Abstract To assess radiological procedures and imaging characteristics in patients with intramammary hematological malignancies (IHM). Radiological imaging studies of histopathological proven IHM cases from ten German University affiliated breast imaging centers from 1997–2012 were retrospectively e...

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Autores principales:	Susanne Wienbeck, Hans Jonas Meyer, Johannes Uhlig, Aimee Herzog, Sogand Nemat, Andrea Teifke, Walter Heindel, Fritz Schäfer, Sonja Kinner, Alexey Surov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a03c103ced35493294f3ee95961a8fd5
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spelling	oai:doaj.org-article:a03c103ced35493294f3ee95961a8fd52021-12-02T15:05:20ZRadiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study10.1038/s41598-017-07409-z2045-2322https://doaj.org/article/a03c103ced35493294f3ee95961a8fd52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07409-zhttps://doaj.org/toc/2045-2322Abstract To assess radiological procedures and imaging characteristics in patients with intramammary hematological malignancies (IHM). Radiological imaging studies of histopathological proven IHM cases from ten German University affiliated breast imaging centers from 1997–2012 were retrospectively evaluated. Imaging modalities included ultrasound (US), mammography and magnetic resonance imaging (MRI). Two radiologists blinded to the histopathological diagnoses independently assessed all imaging studies. Imaging studies of 101 patients with 204 intramammary lesions were included. Most patients were women (95%) with a median age of 64 years. IHM were classified as Non Hodgkin lymphoma (77.2%), plasmacytoma (11.9%), leukemia (9.9%), and Hodgkin lymphoma (1%). The mean lesion size was 15.8 ± 10.1 mm. Most IHM presented in mammography as lesions with comparable density to the surrounding tissue, and a round or irregular shape with indistinct margins. On US, most lesions were of irregular shape with complex echo pattern and indistinct margins. MRI shows lesions with irregular or spiculated margins and miscellaneous enhancement patterns. Using US or MRI, IHM were more frequently classified as BI-RADS 4 or 5 than using mammography (96.2% and 89.3% versus 75.3%). IHM can present with miscellaneous radiological patterns. Sensitivity for detection of IHM lesions was higher in US and MRI than in mammography.Susanne WienbeckHans Jonas MeyerJohannes UhligAimee HerzogSogand NematAndrea TeifkeWalter HeindelFritz SchäferSonja KinnerAlexey SurovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanne Wienbeck Hans Jonas Meyer Johannes Uhlig Aimee Herzog Sogand Nemat Andrea Teifke Walter Heindel Fritz Schäfer Sonja Kinner Alexey Surov Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
description	Abstract To assess radiological procedures and imaging characteristics in patients with intramammary hematological malignancies (IHM). Radiological imaging studies of histopathological proven IHM cases from ten German University affiliated breast imaging centers from 1997–2012 were retrospectively evaluated. Imaging modalities included ultrasound (US), mammography and magnetic resonance imaging (MRI). Two radiologists blinded to the histopathological diagnoses independently assessed all imaging studies. Imaging studies of 101 patients with 204 intramammary lesions were included. Most patients were women (95%) with a median age of 64 years. IHM were classified as Non Hodgkin lymphoma (77.2%), plasmacytoma (11.9%), leukemia (9.9%), and Hodgkin lymphoma (1%). The mean lesion size was 15.8 ± 10.1 mm. Most IHM presented in mammography as lesions with comparable density to the surrounding tissue, and a round or irregular shape with indistinct margins. On US, most lesions were of irregular shape with complex echo pattern and indistinct margins. MRI shows lesions with irregular or spiculated margins and miscellaneous enhancement patterns. Using US or MRI, IHM were more frequently classified as BI-RADS 4 or 5 than using mammography (96.2% and 89.3% versus 75.3%). IHM can present with miscellaneous radiological patterns. Sensitivity for detection of IHM lesions was higher in US and MRI than in mammography.
format	article
author	Susanne Wienbeck Hans Jonas Meyer Johannes Uhlig Aimee Herzog Sogand Nemat Andrea Teifke Walter Heindel Fritz Schäfer Sonja Kinner Alexey Surov
author_facet	Susanne Wienbeck Hans Jonas Meyer Johannes Uhlig Aimee Herzog Sogand Nemat Andrea Teifke Walter Heindel Fritz Schäfer Sonja Kinner Alexey Surov
author_sort	Susanne Wienbeck
title	Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
title_short	Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
title_full	Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
title_fullStr	Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
title_full_unstemmed	Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
title_sort	radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a03c103ced35493294f3ee95961a8fd5
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Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study

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