Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.

<h4>Background</h4>We investigated the serological association of Chlamydia pneumoniae infection with age-related macular degeneration (AMD).<h4>Methods</h4>A systematic review and meta-analysis was performed. PubMed, Embase, Web of Science and the Association of Research in...

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Autores principales:	Xueyu Chen, Vishal Jhanji, Chupeng Chen, Haoyu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0405762058b41ec94c2a647c3e95fbf
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spelling	oai:doaj.org-article:a0405762058b41ec94c2a647c3e95fbf2021-11-25T06:07:03ZSerological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0103466https://doaj.org/article/a0405762058b41ec94c2a647c3e95fbf2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25062085/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We investigated the serological association of Chlamydia pneumoniae infection with age-related macular degeneration (AMD).<h4>Methods</h4>A systematic review and meta-analysis was performed. PubMed, Embase, Web of Science and the Association of Research in Vision and Ophthalmology abstracts were searched to identify studies investigating the serological association of Chlamydia pneumoniae infection with age-related macular degeneration. The quality of original studies was assessed using the Newcastle-Ottawa scale. Heterogeneity was explored with meta-regression. The odds ratios (ORs) and standardized mean differences (SMD) of Chlamydia pneumoniae infection between AMD patients and controls were pooled.<h4>Results</h4>In total, 9 studies met the inclusion criteria using the Newcastle-Ottawa scale scores ranging from 4 to 9. There was heterogeneity among studies due to a difference in the study designs and measurement of exposure to Chlamydia pneumoniae infection. The overall OR of Chlamydia pneumoniae infection with AMD was 1.11 (95% confidence interval: 0.78-1.57, P = 0.56). The overall SMD of antibody titer between AMD and control was 0.43 (95% confidence interval: -0.12 to 0.99, P = 0.13).<h4>Conclusions</h4>Evidence from the current published literature suggested no statistically significant association between Chlamydia pneumoniae infection and AMD.Xueyu ChenVishal JhanjiChupeng ChenHaoyu ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e103466 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueyu Chen Vishal Jhanji Chupeng Chen Haoyu Chen Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
description	<h4>Background</h4>We investigated the serological association of Chlamydia pneumoniae infection with age-related macular degeneration (AMD).<h4>Methods</h4>A systematic review and meta-analysis was performed. PubMed, Embase, Web of Science and the Association of Research in Vision and Ophthalmology abstracts were searched to identify studies investigating the serological association of Chlamydia pneumoniae infection with age-related macular degeneration. The quality of original studies was assessed using the Newcastle-Ottawa scale. Heterogeneity was explored with meta-regression. The odds ratios (ORs) and standardized mean differences (SMD) of Chlamydia pneumoniae infection between AMD patients and controls were pooled.<h4>Results</h4>In total, 9 studies met the inclusion criteria using the Newcastle-Ottawa scale scores ranging from 4 to 9. There was heterogeneity among studies due to a difference in the study designs and measurement of exposure to Chlamydia pneumoniae infection. The overall OR of Chlamydia pneumoniae infection with AMD was 1.11 (95% confidence interval: 0.78-1.57, P = 0.56). The overall SMD of antibody titer between AMD and control was 0.43 (95% confidence interval: -0.12 to 0.99, P = 0.13).<h4>Conclusions</h4>Evidence from the current published literature suggested no statistically significant association between Chlamydia pneumoniae infection and AMD.
format	article
author	Xueyu Chen Vishal Jhanji Chupeng Chen Haoyu Chen
author_facet	Xueyu Chen Vishal Jhanji Chupeng Chen Haoyu Chen
author_sort	Xueyu Chen
title	Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
title_short	Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
title_full	Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
title_fullStr	Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
title_full_unstemmed	Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
title_sort	serological association of chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a0405762058b41ec94c2a647c3e95fbf
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Serological association of Chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis.

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