Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

Identification of clinical relevant biomarkers to predict response to immune checkpoint blockade (ICB) in melanoma remains challenging. Here, the authors show that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-tr...

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Autores principales:	Elena Galvani, Piyushkumar A. Mundra, Sara Valpione, Pablo Garcia-Martinez, Matthew Smith, Jonathan Greenall, Rohit Thakur, Beth Helmink, Miles C. Andrews, Louis Boon, Christopher Chester, Gabriela Gremel, Kate Hogan, Amit Mandal, Kang Zeng, Antonia Banyard, Garry Ashton, Martin Cook, Paul Lorigan, Jennifer A. Wargo, Nathalie Dhomen, Richard Marais
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a043c3f4d304486f94686720bc3b8706
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spelling	oai:doaj.org-article:a043c3f4d304486f94686720bc3b87062021-12-02T15:37:18ZStroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma10.1038/s41467-020-14632-22041-1723https://doaj.org/article/a043c3f4d304486f94686720bc3b87062020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14632-2https://doaj.org/toc/2041-1723Identification of clinical relevant biomarkers to predict response to immune checkpoint blockade (ICB) in melanoma remains challenging. Here, the authors show that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-treated patients.Elena GalvaniPiyushkumar A. MundraSara ValpionePablo Garcia-MartinezMatthew SmithJonathan GreenallRohit ThakurBeth HelminkMiles C. AndrewsLouis BoonChristopher ChesterGabriela GremelKate HoganAmit MandalKang ZengAntonia BanyardGarry AshtonMartin CookPaul LoriganJennifer A. WargoNathalie DhomenRichard MaraisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena Galvani Piyushkumar A. Mundra Sara Valpione Pablo Garcia-Martinez Matthew Smith Jonathan Greenall Rohit Thakur Beth Helmink Miles C. Andrews Louis Boon Christopher Chester Gabriela Gremel Kate Hogan Amit Mandal Kang Zeng Antonia Banyard Garry Ashton Martin Cook Paul Lorigan Jennifer A. Wargo Nathalie Dhomen Richard Marais Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
description	Identification of clinical relevant biomarkers to predict response to immune checkpoint blockade (ICB) in melanoma remains challenging. Here, the authors show that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-treated patients.
format	article
author	Elena Galvani Piyushkumar A. Mundra Sara Valpione Pablo Garcia-Martinez Matthew Smith Jonathan Greenall Rohit Thakur Beth Helmink Miles C. Andrews Louis Boon Christopher Chester Gabriela Gremel Kate Hogan Amit Mandal Kang Zeng Antonia Banyard Garry Ashton Martin Cook Paul Lorigan Jennifer A. Wargo Nathalie Dhomen Richard Marais
author_facet	Elena Galvani Piyushkumar A. Mundra Sara Valpione Pablo Garcia-Martinez Matthew Smith Jonathan Greenall Rohit Thakur Beth Helmink Miles C. Andrews Louis Boon Christopher Chester Gabriela Gremel Kate Hogan Amit Mandal Kang Zeng Antonia Banyard Garry Ashton Martin Cook Paul Lorigan Jennifer A. Wargo Nathalie Dhomen Richard Marais
author_sort	Elena Galvani
title	Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
title_short	Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
title_full	Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
title_fullStr	Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
title_full_unstemmed	Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
title_sort	stroma remodeling and reduced cell division define durable response to pd-1 blockade in melanoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a043c3f4d304486f94686720bc3b8706
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Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

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