Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.

<h4>Background</h4>Current studies showed that idiopathic pulmonary fibrosis (IPF) may lead to a poor prognosis of lung cancer. We conducted a meta-analysis to explore the impact of concomitant IPF in lung cancer and its prognostic value.<h4>Methods</h4>We searched the databa...

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Autores principales:	Haoyu Wang, Ruiyuan Yang, Jing Jin, Zhoufeng Wang, Weimin Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a04646d446a04ba28c73e9ba83d37b48
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spelling	oai:doaj.org-article:a04646d446a04ba28c73e9ba83d37b482021-12-02T20:13:12ZImpact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.1932-620310.1371/journal.pone.0259784https://doaj.org/article/a04646d446a04ba28c73e9ba83d37b482021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259784https://doaj.org/toc/1932-6203<h4>Background</h4>Current studies showed that idiopathic pulmonary fibrosis (IPF) may lead to a poor prognosis of lung cancer. We conducted a meta-analysis to explore the impact of concomitant IPF in lung cancer and its prognostic value.<h4>Methods</h4>We searched the databases of PubMed, Web of Science, Embase up to Feb 10th, 2021 for relevant researches and merged the hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the association between concomitant IPF and overall survival (OS) in patients with lung cancer.<h4>Results</h4>Twelve studies involving 58424 patients were included in our meta-analysis. The results indicated that concomitant IPF was correlated with poor prognosis of lung cancer patients (HR = 1.99, 95%CI, 1.59-2.51). The association remained consistent after subgroup analysis and meta-regression stratified by study region, sample size, tumor histology, and therapy. In addition, our results were robust even after sensitivity analysis.<h4>Conclusions</h4>Concomitant IPF may be a prognostic factor of lung cancer, which can lead to poor survival. However, further studies were necessary for evidence in clinical application.Haoyu WangRuiyuan YangJing JinZhoufeng WangWeimin LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259784 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haoyu Wang Ruiyuan Yang Jing Jin Zhoufeng Wang Weimin Li Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
description	<h4>Background</h4>Current studies showed that idiopathic pulmonary fibrosis (IPF) may lead to a poor prognosis of lung cancer. We conducted a meta-analysis to explore the impact of concomitant IPF in lung cancer and its prognostic value.<h4>Methods</h4>We searched the databases of PubMed, Web of Science, Embase up to Feb 10th, 2021 for relevant researches and merged the hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the association between concomitant IPF and overall survival (OS) in patients with lung cancer.<h4>Results</h4>Twelve studies involving 58424 patients were included in our meta-analysis. The results indicated that concomitant IPF was correlated with poor prognosis of lung cancer patients (HR = 1.99, 95%CI, 1.59-2.51). The association remained consistent after subgroup analysis and meta-regression stratified by study region, sample size, tumor histology, and therapy. In addition, our results were robust even after sensitivity analysis.<h4>Conclusions</h4>Concomitant IPF may be a prognostic factor of lung cancer, which can lead to poor survival. However, further studies were necessary for evidence in clinical application.
format	article
author	Haoyu Wang Ruiyuan Yang Jing Jin Zhoufeng Wang Weimin Li
author_facet	Haoyu Wang Ruiyuan Yang Jing Jin Zhoufeng Wang Weimin Li
author_sort	Haoyu Wang
title	Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
title_short	Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
title_full	Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
title_fullStr	Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
title_full_unstemmed	Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.
title_sort	impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a04646d446a04ba28c73e9ba83d37b48
work_keys_str_mv	AT haoyuwang impactofconcomitantidiopathicpulmonaryfibrosisonprognosisinlungcancerpatientsametaanalysis AT ruiyuanyang impactofconcomitantidiopathicpulmonaryfibrosisonprognosisinlungcancerpatientsametaanalysis AT jingjin impactofconcomitantidiopathicpulmonaryfibrosisonprognosisinlungcancerpatientsametaanalysis AT zhoufengwang impactofconcomitantidiopathicpulmonaryfibrosisonprognosisinlungcancerpatientsametaanalysis AT weiminli impactofconcomitantidiopathicpulmonaryfibrosisonprognosisinlungcancerpatientsametaanalysis
_version_	1718374840799330304

Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis.

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