Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China

The aim was to better understand the clinical characteristics of patients with mucormycosis in western China. We retrospectively investigated the clinical, laboratory, radiological and treatment profiles of mucormycosis patients during a 10-year period (2010–2019). As a result, 59 proven mucormycosi...

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Autores principales:	Junyan Qu, Xijiao Liu, Xiaoju Lv
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mucormycosis pulmonary mucormycosis diabetes clinical analysis clinical outcome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a047d29131a94e8d90d6258debe8b85f
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spelling	oai:doaj.org-article:a047d29131a94e8d90d6258debe8b85f2021-11-22T06:34:32ZPulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China2235-298810.3389/fcimb.2021.770551https://doaj.org/article/a047d29131a94e8d90d6258debe8b85f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.770551/fullhttps://doaj.org/toc/2235-2988The aim was to better understand the clinical characteristics of patients with mucormycosis in western China. We retrospectively investigated the clinical, laboratory, radiological and treatment profiles of mucormycosis patients during a 10-year period (2010–2019). As a result, 59 proven mucormycosis were enrolled in this study. It was found that 52.5% of patients had worse clinical outcomes. Pulmonary mucormycosis (PM) was the most common clinical manifestation. The most frequent risk factor was diabetes mellitus (38, 64.4%) for mucormycosis patients. Cough (43, 93.5%), fever (24, 52.2%) and hemoptysis/bloody phlegm (21, 45.7%) were the most common manifestations of PM. There were no differences in clinical manifestations, risk factors and laboratory tests between different clinical outcome groups (P>0.05). Lymph node enlargement (30, 65.2%), patchy shadows (28, 60.9%), cavitation (25, 53.3%) and bilateral lobe involvement (39, 84.8%) were the most common on chest CT. Nodule was more common in good outcome group (P <0.05). A total of 48 cases (81.4%) were confirmed by histopathological examination, 22 cases (37.3%) were confirmed by direct microscopy. PM patients were treated with amphotericin B/amphotericin B liposome or posaconazale had better clinical outcomes (P <0.05). In conclusion, PM was the most common clinical type of mucormycosis in China. Diabetes mellitus was the most common risk factor. PM has diverse imaging manifestations and was prone to bilateral lobes involvement. Early diagnosis and effective anti-mucor treatment contribute to successful treatment.Junyan QuXijiao LiuXiaoju LvFrontiers Media S.A.articlemucormycosispulmonary mucormycosisdiabetesclinical analysisclinical outcomeMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mucormycosis pulmonary mucormycosis diabetes clinical analysis clinical outcome Microbiology QR1-502
spellingShingle	mucormycosis pulmonary mucormycosis diabetes clinical analysis clinical outcome Microbiology QR1-502 Junyan Qu Xijiao Liu Xiaoju Lv Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
description	The aim was to better understand the clinical characteristics of patients with mucormycosis in western China. We retrospectively investigated the clinical, laboratory, radiological and treatment profiles of mucormycosis patients during a 10-year period (2010–2019). As a result, 59 proven mucormycosis were enrolled in this study. It was found that 52.5% of patients had worse clinical outcomes. Pulmonary mucormycosis (PM) was the most common clinical manifestation. The most frequent risk factor was diabetes mellitus (38, 64.4%) for mucormycosis patients. Cough (43, 93.5%), fever (24, 52.2%) and hemoptysis/bloody phlegm (21, 45.7%) were the most common manifestations of PM. There were no differences in clinical manifestations, risk factors and laboratory tests between different clinical outcome groups (P>0.05). Lymph node enlargement (30, 65.2%), patchy shadows (28, 60.9%), cavitation (25, 53.3%) and bilateral lobe involvement (39, 84.8%) were the most common on chest CT. Nodule was more common in good outcome group (P <0.05). A total of 48 cases (81.4%) were confirmed by histopathological examination, 22 cases (37.3%) were confirmed by direct microscopy. PM patients were treated with amphotericin B/amphotericin B liposome or posaconazale had better clinical outcomes (P <0.05). In conclusion, PM was the most common clinical type of mucormycosis in China. Diabetes mellitus was the most common risk factor. PM has diverse imaging manifestations and was prone to bilateral lobes involvement. Early diagnosis and effective anti-mucor treatment contribute to successful treatment.
format	article
author	Junyan Qu Xijiao Liu Xiaoju Lv
author_facet	Junyan Qu Xijiao Liu Xiaoju Lv
author_sort	Junyan Qu
title	Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
title_short	Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
title_full	Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
title_fullStr	Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
title_full_unstemmed	Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China
title_sort	pulmonary mucormycosis as the leading clinical type of mucormycosis in western china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a047d29131a94e8d90d6258debe8b85f
work_keys_str_mv	AT junyanqu pulmonarymucormycosisastheleadingclinicaltypeofmucormycosisinwesternchina AT xijiaoliu pulmonarymucormycosisastheleadingclinicaltypeofmucormycosisinwesternchina AT xiaojulv pulmonarymucormycosisastheleadingclinicaltypeofmucormycosisinwesternchina
_version_	1718418117864980480

Pulmonary Mucormycosis as the Leading Clinical Type of Mucormycosis in Western China

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