Study on Motion Management of Pancreatic Cancer Treated by CyberKnife

PurposeWe investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target.Methods...

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Autores principales:	Shenghua Jing, Changchen Jiang, Xiaoqin Ji, Xiangnan Qiu, Jing Li, Xiangdong Sun, Xixu Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CyberKnife expansion margin pancreatic cancer SRTS tumor motion management Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a04956752a444bc5a54ef18f9a44caee
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spelling	oai:doaj.org-article:a04956752a444bc5a54ef18f9a44caee2021-12-02T08:43:47ZStudy on Motion Management of Pancreatic Cancer Treated by CyberKnife2234-943X10.3389/fonc.2021.767832https://doaj.org/article/a04956752a444bc5a54ef18f9a44caee2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.767832/fullhttps://doaj.org/toc/2234-943XPurposeWe investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target.Methods and MaterialsForty-two patients with pancreatic cancer treated by CyberKnife were retrospectively studied. The pancreatic displacement calculated from the x-ray images collected during the time interval between two consecutive movements constituted a data set.ResultsThe total mean motion amplitudes and standard deviations of pancreatic tumors in SI, LR, AP, and radial directions were 3.66 ± 1.71 mm, 0.97 ± 0.62 mm, 1.52 ± 1.02 mm, and 1.36 ± 0.49 mm, respectively. The overall mean correlation errors and standard deviations were 0.82 ± 0.46 mm, 0.47 ± 0.33 mm, 0.41 ± 0.24 mm, and 0.98 ± 0.37 mm, respectively. The overall mean prediction errors and standard deviations were 0.57 ± 0.14 mm, 0.62 ± 0.28 mm, 0.39 ± 0.17 mm, and 1.58 ± 0.36 mm, respectively. The correlation errors and prediction errors of pancreatic tumors at different anatomical positions in SI, LR, and AP directions were statistically significant (p < 0.05).ConclusionsThe tumor motion amplitude, the tumor location, and the treatment time are the main factors affecting the tracking accuracy. The pancreatic tumors at different anatomical locations should be treated differently to ensure sufficient dose coverage of the pancreatic target area.Shenghua JingChangchen JiangXiaoqin JiXiangnan QiuJing LiXiangdong SunXixu ZhuFrontiers Media S.A.articleCyberKnifeexpansion marginpancreatic cancerSRTStumor motion managementNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CyberKnife expansion margin pancreatic cancer SRTS tumor motion management Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CyberKnife expansion margin pancreatic cancer SRTS tumor motion management Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shenghua Jing Changchen Jiang Xiaoqin Ji Xiangnan Qiu Jing Li Xiangdong Sun Xixu Zhu Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
description	PurposeWe investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target.Methods and MaterialsForty-two patients with pancreatic cancer treated by CyberKnife were retrospectively studied. The pancreatic displacement calculated from the x-ray images collected during the time interval between two consecutive movements constituted a data set.ResultsThe total mean motion amplitudes and standard deviations of pancreatic tumors in SI, LR, AP, and radial directions were 3.66 ± 1.71 mm, 0.97 ± 0.62 mm, 1.52 ± 1.02 mm, and 1.36 ± 0.49 mm, respectively. The overall mean correlation errors and standard deviations were 0.82 ± 0.46 mm, 0.47 ± 0.33 mm, 0.41 ± 0.24 mm, and 0.98 ± 0.37 mm, respectively. The overall mean prediction errors and standard deviations were 0.57 ± 0.14 mm, 0.62 ± 0.28 mm, 0.39 ± 0.17 mm, and 1.58 ± 0.36 mm, respectively. The correlation errors and prediction errors of pancreatic tumors at different anatomical positions in SI, LR, and AP directions were statistically significant (p < 0.05).ConclusionsThe tumor motion amplitude, the tumor location, and the treatment time are the main factors affecting the tracking accuracy. The pancreatic tumors at different anatomical locations should be treated differently to ensure sufficient dose coverage of the pancreatic target area.
format	article
author	Shenghua Jing Changchen Jiang Xiaoqin Ji Xiangnan Qiu Jing Li Xiangdong Sun Xixu Zhu
author_facet	Shenghua Jing Changchen Jiang Xiaoqin Ji Xiangnan Qiu Jing Li Xiangdong Sun Xixu Zhu
author_sort	Shenghua Jing
title	Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
title_short	Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
title_full	Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
title_fullStr	Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
title_full_unstemmed	Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
title_sort	study on motion management of pancreatic cancer treated by cyberknife
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a04956752a444bc5a54ef18f9a44caee
work_keys_str_mv	AT shenghuajing studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT changchenjiang studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT xiaoqinji studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT xiangnanqiu studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT jingli studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT xiangdongsun studyonmotionmanagementofpancreaticcancertreatedbycyberknife AT xixuzhu studyonmotionmanagementofpancreaticcancertreatedbycyberknife
_version_	1718398429086875648

Study on Motion Management of Pancreatic Cancer Treated by CyberKnife

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