Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy

Psychiatric disorders seem to be characterized by premature cell senescence. However, controversial results have also been reported. In addition, the relationship between accelerated aging and treatment-resistance has scarcely been investigated. In the current study, we measured leukocyte telomere l...

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Autores principales:	Claudia Pisanu, Erika Vitali, Anna Meloni, Donatella Congiu, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Luigi Trabucchi, Marco Bortolomasi, Massimo Gennarelli, Alessandra Minelli, Alessio Squassina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	telomere ECT treatment-resistance accelerated aging psychiatric disorders mental disorders Medicine R
Acceso en línea:	https://doaj.org/article/a04ddffa864e4bb5a094fe7becf43891
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spelling	oai:doaj.org-article:a04ddffa864e4bb5a094fe7becf438912021-11-25T18:07:11ZInvestigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy10.3390/jpm111111002075-4426https://doaj.org/article/a04ddffa864e4bb5a094fe7becf438912021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1100https://doaj.org/toc/2075-4426Psychiatric disorders seem to be characterized by premature cell senescence. However, controversial results have also been reported. In addition, the relationship between accelerated aging and treatment-resistance has scarcely been investigated. In the current study, we measured leukocyte telomere length (LTL) in 148 patients with treatment-resistant depression (TRD, 125 with major depressive disorder, MDD, and 23 with bipolar disorder, BD) treated with electroconvulsive therapy (ECT) and analyzed whether LTL was associated with different response profiles. We also compared LTL between patients with TRD and 335 non-psychiatric controls. For 107 patients for which genome-wide association data were available, we evaluated whether a significant overlap among genetic variants or genes associated with LTL and with response to ECT could be observed. LTL was negatively correlated with age (Spearman’s correlation coefficient = −0.25, <i>p</i> < 0.0001) and significantly shorter in patients with treatment-resistant MDD (Quade’s F = 35.18, <i>p</i> < 0.0001) or BD (Quade’s F = 20.84, <i>p</i> < 0.0001) compared to controls. Conversely, baseline LTL was not associated with response to ECT or remission. We did not detect any significant overlap between genetic variants or genes associated with LTL and response to ECT. Our results support previous findings suggesting premature cell senescence in patients with severe psychiatric disorders and suggest that LTL could not be a predictive biomarker of response to ECT.Claudia PisanuErika VitaliAnna MeloniDonatella CongiuGiovanni SeverinoRaffaella ArdauCaterina ChillottiLuigi TrabucchiMarco BortolomasiMassimo GennarelliAlessandra MinelliAlessio SquassinaMDPI AGarticletelomereECTtreatment-resistanceaccelerated agingpsychiatric disordersmental disordersMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1100, p 1100 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	telomere ECT treatment-resistance accelerated aging psychiatric disorders mental disorders Medicine R
spellingShingle	telomere ECT treatment-resistance accelerated aging psychiatric disorders mental disorders Medicine R Claudia Pisanu Erika Vitali Anna Meloni Donatella Congiu Giovanni Severino Raffaella Ardau Caterina Chillotti Luigi Trabucchi Marco Bortolomasi Massimo Gennarelli Alessandra Minelli Alessio Squassina Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
description	Psychiatric disorders seem to be characterized by premature cell senescence. However, controversial results have also been reported. In addition, the relationship between accelerated aging and treatment-resistance has scarcely been investigated. In the current study, we measured leukocyte telomere length (LTL) in 148 patients with treatment-resistant depression (TRD, 125 with major depressive disorder, MDD, and 23 with bipolar disorder, BD) treated with electroconvulsive therapy (ECT) and analyzed whether LTL was associated with different response profiles. We also compared LTL between patients with TRD and 335 non-psychiatric controls. For 107 patients for which genome-wide association data were available, we evaluated whether a significant overlap among genetic variants or genes associated with LTL and with response to ECT could be observed. LTL was negatively correlated with age (Spearman’s correlation coefficient = −0.25, <i>p</i> < 0.0001) and significantly shorter in patients with treatment-resistant MDD (Quade’s F = 35.18, <i>p</i> < 0.0001) or BD (Quade’s F = 20.84, <i>p</i> < 0.0001) compared to controls. Conversely, baseline LTL was not associated with response to ECT or remission. We did not detect any significant overlap between genetic variants or genes associated with LTL and response to ECT. Our results support previous findings suggesting premature cell senescence in patients with severe psychiatric disorders and suggest that LTL could not be a predictive biomarker of response to ECT.
format	article
author	Claudia Pisanu Erika Vitali Anna Meloni Donatella Congiu Giovanni Severino Raffaella Ardau Caterina Chillotti Luigi Trabucchi Marco Bortolomasi Massimo Gennarelli Alessandra Minelli Alessio Squassina
author_facet	Claudia Pisanu Erika Vitali Anna Meloni Donatella Congiu Giovanni Severino Raffaella Ardau Caterina Chillotti Luigi Trabucchi Marco Bortolomasi Massimo Gennarelli Alessandra Minelli Alessio Squassina
author_sort	Claudia Pisanu
title	Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
title_short	Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
title_full	Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
title_fullStr	Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
title_full_unstemmed	Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
title_sort	investigating the role of leukocyte telomere length in treatment-resistant depression and in response to electroconvulsive therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a04ddffa864e4bb5a094fe7becf43891
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Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy

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