Aggressive retinal astrocytoma associated with tuberous sclerosis

Machiko Tomida,1 Yoshinori Mitamura,1 Takashi Katome,1 Hiroshi Eguchi,1 Takeshi Naito,1 Takayuki Harada21Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 2Visual Research Project, Tokyo Metropolitan Institute of Medical Science, To...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomida M, Mitamura Y, Katome T, Eguchi H, Naito T, Harada T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a05488285b724b34be92d0ace929a693
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a05488285b724b34be92d0ace929a693
record_format	dspace
spelling	oai:doaj.org-article:a05488285b724b34be92d0ace929a6932021-12-02T05:18:15ZAggressive retinal astrocytoma associated with tuberous sclerosis1177-54671177-5483https://doaj.org/article/a05488285b724b34be92d0ace929a6932012-05-01T00:00:00Zhttp://www.dovepress.com/aggressive-retinal-astrocytoma-associated-with-tuberous-sclerosis-a9869https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Machiko Tomida,1 Yoshinori Mitamura,1 Takashi Katome,1 Hiroshi Eguchi,1 Takeshi Naito,1 Takayuki Harada21Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 2Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, JapanAbstract: We report the case of a patient with an aggressive retinal astrocytoma accompanied with macular edema and neovascular vessels, who was initially treated with intravitreal bevacizumab injections. A 24-year-old male presented to our clinic complaining of visual disturbance in his right eye. At 8 years of age, he had been diagnosed as having tuberous sclerosis complex. Fundus examination demonstrated a retinal tumor accompanied with marked neovascular vessels on the surface, retinal hemorrhage, and macular edema. After six monthly intravitreal bevacizumab injections, fundus examination demonstrated marked regression of the macular edema and neovascular vessels. Two months later, a vitreous hemorrhage developed which necessitated pars plana vitrectomy. After additional intravitreal bevacizumab injection for preventing intraoperative bleeding, vitrectomy with endophotocoagulation for the tumor was performed. The vitreous sample was obtained during vitrectomy, and we measured the vascular endothelial growth factor concentration by enzyme-linked immunosorbent assay. The surgically removed epiretinal neovascular membrane and biopsied retinal tumor expressed vascular endothelial growth factor, although several intravitreal bevacizumab injections led to a vitreous vascular endothelial growth factor concentration of undetectable levels. The clinical course and immunohistochemical analyses indicate that intravitreal bevacizumab monotherapy may have been insufficient to treat the aggressive retinal astrocytoma with macular edema and that laser photocoagulation or photodynamic therapy for the tumor should be considered following intravitreal bevacizumab injection in such cases.Keywords: aggressive retinal astrocytoma, bevacizumab, macular edema, tuberous sclerosis, vitrectomy, vitreous hemorrhage&nbsp;Tomida MMitamura YKatome TEguchi HNaito THarada TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 715-720 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tomida M Mitamura Y Katome T Eguchi H Naito T Harada T Aggressive retinal astrocytoma associated with tuberous sclerosis
description	Machiko Tomida,1 Yoshinori Mitamura,1 Takashi Katome,1 Hiroshi Eguchi,1 Takeshi Naito,1 Takayuki Harada21Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 2Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, JapanAbstract: We report the case of a patient with an aggressive retinal astrocytoma accompanied with macular edema and neovascular vessels, who was initially treated with intravitreal bevacizumab injections. A 24-year-old male presented to our clinic complaining of visual disturbance in his right eye. At 8 years of age, he had been diagnosed as having tuberous sclerosis complex. Fundus examination demonstrated a retinal tumor accompanied with marked neovascular vessels on the surface, retinal hemorrhage, and macular edema. After six monthly intravitreal bevacizumab injections, fundus examination demonstrated marked regression of the macular edema and neovascular vessels. Two months later, a vitreous hemorrhage developed which necessitated pars plana vitrectomy. After additional intravitreal bevacizumab injection for preventing intraoperative bleeding, vitrectomy with endophotocoagulation for the tumor was performed. The vitreous sample was obtained during vitrectomy, and we measured the vascular endothelial growth factor concentration by enzyme-linked immunosorbent assay. The surgically removed epiretinal neovascular membrane and biopsied retinal tumor expressed vascular endothelial growth factor, although several intravitreal bevacizumab injections led to a vitreous vascular endothelial growth factor concentration of undetectable levels. The clinical course and immunohistochemical analyses indicate that intravitreal bevacizumab monotherapy may have been insufficient to treat the aggressive retinal astrocytoma with macular edema and that laser photocoagulation or photodynamic therapy for the tumor should be considered following intravitreal bevacizumab injection in such cases.Keywords: aggressive retinal astrocytoma, bevacizumab, macular edema, tuberous sclerosis, vitrectomy, vitreous hemorrhage&nbsp;
format	article
author	Tomida M Mitamura Y Katome T Eguchi H Naito T Harada T
author_facet	Tomida M Mitamura Y Katome T Eguchi H Naito T Harada T
author_sort	Tomida M
title	Aggressive retinal astrocytoma associated with tuberous sclerosis
title_short	Aggressive retinal astrocytoma associated with tuberous sclerosis
title_full	Aggressive retinal astrocytoma associated with tuberous sclerosis
title_fullStr	Aggressive retinal astrocytoma associated with tuberous sclerosis
title_full_unstemmed	Aggressive retinal astrocytoma associated with tuberous sclerosis
title_sort	aggressive retinal astrocytoma associated with tuberous sclerosis
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/a05488285b724b34be92d0ace929a693
work_keys_str_mv	AT tomidam aggressiveretinalastrocytomaassociatedwithtuberoussclerosis AT mitamuray aggressiveretinalastrocytomaassociatedwithtuberoussclerosis AT katomet aggressiveretinalastrocytomaassociatedwithtuberoussclerosis AT eguchih aggressiveretinalastrocytomaassociatedwithtuberoussclerosis AT naitot aggressiveretinalastrocytomaassociatedwithtuberoussclerosis AT haradat aggressiveretinalastrocytomaassociatedwithtuberoussclerosis
_version_	1718400486751600640

Aggressive retinal astrocytoma associated with tuberous sclerosis

Ejemplares similares