Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic

Background:When acquired during pregnancy, Zika virus (ZIKV) infection can cause substantial fetal morbidity, however, little is known about the long-term neurodevelopmental abnormalities of infants with congenital ZIKV exposure without microcephaly at birth. Methods:We conducted a cross sectional s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Raquel Pimentel, Shaveta Khosla, Josefina Rondon, Farah Pena, Gwyneth Sullivan, Martha Perez, Supriya D. Mehta, Maximo O. Brito
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/a055142244434dab876dd12ce45459f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a055142244434dab876dd12ce45459f8
record_format	dspace
spelling	oai:doaj.org-article:a055142244434dab876dd12ce45459f82021-12-02T14:22:52ZBirth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic2214-999610.5334/aogh.3095https://doaj.org/article/a055142244434dab876dd12ce45459f82021-01-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/3095https://doaj.org/toc/2214-9996Background:When acquired during pregnancy, Zika virus (ZIKV) infection can cause substantial fetal morbidity, however, little is known about the long-term neurodevelopmental abnormalities of infants with congenital ZIKV exposure without microcephaly at birth. Methods:We conducted a cross sectional study to characterize infants born with microcephaly, and a retrospective cohort study of infants who appeared well at birth, but had possible congenital ZIKV exposure. We analyzed data from the Dominican Ministry of Health’s (MoH) National System of Epidemiological Surveillance. Neurodevelopmental abnormalities were assessed by pediatric neurologists over an 18-month period using Denver Developmental Screening Test II. Results:Of 800 known live births from 1,364 women with suspected or confirmed ZIKV infection during pregnancy, 87 (11%) infants had confirmed microcephaly. Mean head circumference (HC) at birth was 28.1 cm (SD ± 2.1 cm) and 41% had a HC on the zero percentile for gestational age. Of 42 infants with possible congenital ZIKV exposure followed longitudinally, 52% had neurodevelopmental abnormalities, including two cases of postnatal onset microcephaly, during follow-up. Most abnormalities resolved, though two infants (4%) had neurodevelopmental abnormalities that were likely associated with ZIKV infection and persisted through 15–18 months. Conclusions:In the DR epidemic, 11% of infants born to women reported to the MoH with suspected or confirmed ZIKV during pregnancy had microcephaly. Some 4% of ZKV-exposed infants developed postnatal neurocognitive abnormalities. Monitoring of the cohort through late childhood and adolescence is needed.Raquel PimentelShaveta KhoslaJosefina RondonFarah PenaGwyneth SullivanMartha PerezSupriya D. MehtaMaximo O. BritoUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 87, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Raquel Pimentel Shaveta Khosla Josefina Rondon Farah Pena Gwyneth Sullivan Martha Perez Supriya D. Mehta Maximo O. Brito Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
description	Background:When acquired during pregnancy, Zika virus (ZIKV) infection can cause substantial fetal morbidity, however, little is known about the long-term neurodevelopmental abnormalities of infants with congenital ZIKV exposure without microcephaly at birth. Methods:We conducted a cross sectional study to characterize infants born with microcephaly, and a retrospective cohort study of infants who appeared well at birth, but had possible congenital ZIKV exposure. We analyzed data from the Dominican Ministry of Health’s (MoH) National System of Epidemiological Surveillance. Neurodevelopmental abnormalities were assessed by pediatric neurologists over an 18-month period using Denver Developmental Screening Test II. Results:Of 800 known live births from 1,364 women with suspected or confirmed ZIKV infection during pregnancy, 87 (11%) infants had confirmed microcephaly. Mean head circumference (HC) at birth was 28.1 cm (SD ± 2.1 cm) and 41% had a HC on the zero percentile for gestational age. Of 42 infants with possible congenital ZIKV exposure followed longitudinally, 52% had neurodevelopmental abnormalities, including two cases of postnatal onset microcephaly, during follow-up. Most abnormalities resolved, though two infants (4%) had neurodevelopmental abnormalities that were likely associated with ZIKV infection and persisted through 15–18 months. Conclusions:In the DR epidemic, 11% of infants born to women reported to the MoH with suspected or confirmed ZIKV during pregnancy had microcephaly. Some 4% of ZKV-exposed infants developed postnatal neurocognitive abnormalities. Monitoring of the cohort through late childhood and adolescence is needed.
format	article
author	Raquel Pimentel Shaveta Khosla Josefina Rondon Farah Pena Gwyneth Sullivan Martha Perez Supriya D. Mehta Maximo O. Brito
author_facet	Raquel Pimentel Shaveta Khosla Josefina Rondon Farah Pena Gwyneth Sullivan Martha Perez Supriya D. Mehta Maximo O. Brito
author_sort	Raquel Pimentel
title	Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
title_short	Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
title_full	Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
title_fullStr	Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
title_full_unstemmed	Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic
title_sort	birth defects and long- term neurodevelopmental abnormalities in infants born during the zika virus epidemic in the dominican republic
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/a055142244434dab876dd12ce45459f8
work_keys_str_mv	AT raquelpimentel birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT shavetakhosla birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT josefinarondon birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT farahpena birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT gwynethsullivan birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT marthaperez birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT supriyadmehta birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic AT maximoobrito birthdefectsandlongtermneurodevelopmentalabnormalitiesininfantsbornduringthezikavirusepidemicinthedominicanrepublic
_version_	1718391505527242752

Birth Defects and Long- Term Neurodevelopmental Abnormalities in Infants Born During the Zika Virus Epidemic in the Dominican Republic

Ejemplares similares