Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

Type III CRISPR-Cas RNases from the Csm and Csx families are activated by cyclic oligoadenylates (cOA). Here the authors present the cOA bound Sulfolobus islandicus Csx1 structure, which forms a hexamer and reveal an allosteric mechanism for the activation of Csx1 RNase.

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Autores principales:	Rafael Molina, Stefano Stella, Mingxia Feng, Nicholas Sofos, Vykintas Jauniskis, Irina Pozdnyakova, Blanca López-Méndez, Qunxin She, Guillermo Montoya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0552bfd06e54104982c7ac8deb8d5c3
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spelling	oai:doaj.org-article:a0552bfd06e54104982c7ac8deb8d5c32021-12-02T14:39:16ZStructure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas10.1038/s41467-019-12244-z2041-1723https://doaj.org/article/a0552bfd06e54104982c7ac8deb8d5c32019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12244-zhttps://doaj.org/toc/2041-1723Type III CRISPR-Cas RNases from the Csm and Csx families are activated by cyclic oligoadenylates (cOA). Here the authors present the cOA bound Sulfolobus islandicus Csx1 structure, which forms a hexamer and reveal an allosteric mechanism for the activation of Csx1 RNase.Rafael MolinaStefano StellaMingxia FengNicholas SofosVykintas JauniskisIrina PozdnyakovaBlanca López-MéndezQunxin SheGuillermo MontoyaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Molina Stefano Stella Mingxia Feng Nicholas Sofos Vykintas Jauniskis Irina Pozdnyakova Blanca López-Méndez Qunxin She Guillermo Montoya Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
description	Type III CRISPR-Cas RNases from the Csm and Csx families are activated by cyclic oligoadenylates (cOA). Here the authors present the cOA bound Sulfolobus islandicus Csx1 structure, which forms a hexamer and reveal an allosteric mechanism for the activation of Csx1 RNase.
format	article
author	Rafael Molina Stefano Stella Mingxia Feng Nicholas Sofos Vykintas Jauniskis Irina Pozdnyakova Blanca López-Méndez Qunxin She Guillermo Montoya
author_facet	Rafael Molina Stefano Stella Mingxia Feng Nicholas Sofos Vykintas Jauniskis Irina Pozdnyakova Blanca López-Méndez Qunxin She Guillermo Montoya
author_sort	Rafael Molina
title	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
title_short	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
title_full	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
title_fullStr	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
title_full_unstemmed	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
title_sort	structure of csx1-coa4 complex reveals the basis of rna decay in type iii-b crispr-cas
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a0552bfd06e54104982c7ac8deb8d5c3
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Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

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