Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia

Burak Kulaksizoglu,1 Sibel Kulaksizoglu2 1Psychiatry Department, Antalya Education and Research Hospital, 2Biochemistry Department, Antalya Education and Research Hospital, Antalya, Turkey Introduction: The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR)...

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Autores principales:	Kulaksizoglu B, Kulaksizoglu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	neutrophil/lymphocyte ratio oxidative stres schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a0578fac955d43279bb34b65fdbb4310
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spelling	oai:doaj.org-article:a0578fac955d43279bb34b65fdbb43102021-12-02T00:48:47ZRelationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia1178-2021https://doaj.org/article/a0578fac955d43279bb34b65fdbb43102016-08-01T00:00:00Zhttps://www.dovepress.com/relationship-between-neutrophillymphocyte-ratio-with-oxidative-stress--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Burak Kulaksizoglu,1 Sibel Kulaksizoglu2 1Psychiatry Department, Antalya Education and Research Hospital, 2Biochemistry Department, Antalya Education and Research Hospital, Antalya, Turkey Introduction: The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), paraoxonase, and total thiol (T.thl) in schizophrenic patients compared to healthy control group and investigate the relationship between these parameters and psychopathological symptoms.Methods: The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.Results: Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.Conclusion: By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients’ clinical symptoms. Keywords: oxidative stress, antioxidant status, PANSS, schizophreniaKulaksizoglu BKulaksizoglu SDove Medical Pressarticleneutrophil/lymphocyte ratiooxidative stresschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 1999-2005 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil/lymphocyte ratio oxidative stres schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neutrophil/lymphocyte ratio oxidative stres schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kulaksizoglu B Kulaksizoglu S Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
description	Burak Kulaksizoglu,1 Sibel Kulaksizoglu2 1Psychiatry Department, Antalya Education and Research Hospital, 2Biochemistry Department, Antalya Education and Research Hospital, Antalya, Turkey Introduction: The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), paraoxonase, and total thiol (T.thl) in schizophrenic patients compared to healthy control group and investigate the relationship between these parameters and psychopathological symptoms.Methods: The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.Results: Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.Conclusion: By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients’ clinical symptoms. Keywords: oxidative stress, antioxidant status, PANSS, schizophrenia
format	article
author	Kulaksizoglu B Kulaksizoglu S
author_facet	Kulaksizoglu B Kulaksizoglu S
author_sort	Kulaksizoglu B
title	Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
title_short	Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
title_full	Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
title_fullStr	Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
title_full_unstemmed	Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
title_sort	relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a0578fac955d43279bb34b65fdbb4310
work_keys_str_mv	AT kulaksizoglub relationshipbetweenneutrophillymphocyteratiowithoxidativestressandpsychopathologyinpatientswithschizophrenia AT kulaksizoglus relationshipbetweenneutrophillymphocyteratiowithoxidativestressandpsychopathologyinpatientswithschizophrenia
_version_	1718403455927713792

Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia

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