The IL-33/sST2 Axis in Thromboangiitis Obliterans

Hiva Sharebiani,1 Mehran Mohareri,1 Ali Mirhosseini,1 Bahare Fazeli1,2 1Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Vascular Independent Research and Education, European Foundation, Milan, It...

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Autores principales:	Sharebiani H, Mohareri M, Mirhosseini A, Fazeli B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	interleukin 33 soluble st2 buerger’s disease thromboangiitis obliterans vasculitis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a0582a9fc0334d04aa514d6dc13c8909
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spelling	oai:doaj.org-article:a0582a9fc0334d04aa514d6dc13c89092021-12-02T10:33:52ZThe IL-33/sST2 Axis in Thromboangiitis Obliterans1178-7031https://doaj.org/article/a0582a9fc0334d04aa514d6dc13c89092020-07-01T00:00:00Zhttps://www.dovepress.com/the-il-33sst2-axis-in-thromboangiitis-obliterans-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Hiva Sharebiani,1 Mehran Mohareri,1 Ali Mirhosseini,1 Bahare Fazeli1,2 1Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Vascular Independent Research and Education, European Foundation, Milan, ItalyCorrespondence: Bahare FazeliImmunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranTel +985138002379Fax +985138414499WhatsApp ID +98 9151108249 Email bahar.fazeli@gmail.comBackground: Until recently, it remains unknown whether thromboangiitis obliterans (TAO) is a type of systemic vasculitis. A high level of IL-33 and its soluble decoy receptor sST2 in the acute phase of systemic vasculitis has been demonstrated.Methods: The serum level of IL-33 and sST2 in 50 TAO patients, 20 age- and smoking habit-matched controls and 19 age-matched non-smoker controls was evaluated.Results: The mean level of IL-33 in TAO, smokers and non-smokers was 370.2± 61.7ng/mL,132.14± 2.6ng/mL and 11.3± 0.38ng/mL, respectively. The IL-33 was significantly higher in the TAO than in either control groups (p < 0.001). The IL-33 in the acute phase of TAO was significantly higher than in the patients in the quiescent phase of the disease (p = 0.019). Also, IL-33 in the patients with gangrene was significantly higher than in the patients with non-healing ulcers (p = 0.021). The sST2 in the TAO patients was 49.3± 5.58ng/mL, and in smoker and non-smoker controls, it was 45.3± 6.3ng/mL and 4.11± 0.17ng/mL, respectively. No significant difference was found between the patients and smoker control groups (p = 0.87). The mean ratio of IL-33/sST2 was 27.89± 10.44 in the TAO group and, in smokers and non-smokers, it was 2.85± 0.48 and 2.84± 0.14, respectively. A significantly high level of IL-33/sST2 ratio was observed in TAO patients in both the active and quiescent phases of the disease in comparison to both control groups (p< 0.001).Conclusion: The regulation pattern of IL-33/sST2 was different in TAO in comparison to autoimmune vasculitis.Keywords: interleukin 33, soluble ST2, Buerger’s disease, thromboangiitis obliterans, vasculitisSharebiani HMohareri MMirhosseini AFazeli BDove Medical Pressarticleinterleukin 33soluble st2buerger’s diseasethromboangiitis obliteransvasculitisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 317-323 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	interleukin 33 soluble st2 buerger’s disease thromboangiitis obliterans vasculitis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	interleukin 33 soluble st2 buerger’s disease thromboangiitis obliterans vasculitis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Sharebiani H Mohareri M Mirhosseini A Fazeli B The IL-33/sST2 Axis in Thromboangiitis Obliterans
description	Hiva Sharebiani,1 Mehran Mohareri,1 Ali Mirhosseini,1 Bahare Fazeli1,2 1Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Vascular Independent Research and Education, European Foundation, Milan, ItalyCorrespondence: Bahare FazeliImmunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranTel +985138002379Fax +985138414499WhatsApp ID +98 9151108249 Email bahar.fazeli@gmail.comBackground: Until recently, it remains unknown whether thromboangiitis obliterans (TAO) is a type of systemic vasculitis. A high level of IL-33 and its soluble decoy receptor sST2 in the acute phase of systemic vasculitis has been demonstrated.Methods: The serum level of IL-33 and sST2 in 50 TAO patients, 20 age- and smoking habit-matched controls and 19 age-matched non-smoker controls was evaluated.Results: The mean level of IL-33 in TAO, smokers and non-smokers was 370.2± 61.7ng/mL,132.14± 2.6ng/mL and 11.3± 0.38ng/mL, respectively. The IL-33 was significantly higher in the TAO than in either control groups (p < 0.001). The IL-33 in the acute phase of TAO was significantly higher than in the patients in the quiescent phase of the disease (p = 0.019). Also, IL-33 in the patients with gangrene was significantly higher than in the patients with non-healing ulcers (p = 0.021). The sST2 in the TAO patients was 49.3± 5.58ng/mL, and in smoker and non-smoker controls, it was 45.3± 6.3ng/mL and 4.11± 0.17ng/mL, respectively. No significant difference was found between the patients and smoker control groups (p = 0.87). The mean ratio of IL-33/sST2 was 27.89± 10.44 in the TAO group and, in smokers and non-smokers, it was 2.85± 0.48 and 2.84± 0.14, respectively. A significantly high level of IL-33/sST2 ratio was observed in TAO patients in both the active and quiescent phases of the disease in comparison to both control groups (p< 0.001).Conclusion: The regulation pattern of IL-33/sST2 was different in TAO in comparison to autoimmune vasculitis.Keywords: interleukin 33, soluble ST2, Buerger’s disease, thromboangiitis obliterans, vasculitis
format	article
author	Sharebiani H Mohareri M Mirhosseini A Fazeli B
author_facet	Sharebiani H Mohareri M Mirhosseini A Fazeli B
author_sort	Sharebiani H
title	The IL-33/sST2 Axis in Thromboangiitis Obliterans
title_short	The IL-33/sST2 Axis in Thromboangiitis Obliterans
title_full	The IL-33/sST2 Axis in Thromboangiitis Obliterans
title_fullStr	The IL-33/sST2 Axis in Thromboangiitis Obliterans
title_full_unstemmed	The IL-33/sST2 Axis in Thromboangiitis Obliterans
title_sort	il-33/sst2 axis in thromboangiitis obliterans
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/a0582a9fc0334d04aa514d6dc13c8909
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The IL-33/sST2 Axis in Thromboangiitis Obliterans

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