Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression.

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression.

Kaposi's Sarcoma (KS), caused by Kaposi's Sarcoma Herpesvirus (KSHV), is a highly vascularised angiogenic tumor of endothelial cells, characterized by latently KSHV-infected spindle cells and a pronounced inflammatory infiltrate. Several KSHV proteins, including LANA-1 (ORF73), vCyclin (OR...

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Bibliographic Details
Main Authors: Kiran Bala, Raffaella Bosco, Silvia Gramolelli, Darya A Haas, Semra Kati, Marcel Pietrek, Anika Hävemeier, Yuri Yakushko, Vivek Vikram Singh, Oliver Dittrich-Breiholz, Michael Kracht, Thomas F Schulz
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/a0582c725b0c45019648cc978a532021
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https://doaj.org/article/a0582c725b0c45019648cc978a532021

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