Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action

Lina Nordquist1, Fredrik Palm1,2, Bradley T Andresen3,41Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden; 2Georgetown University Medical Center, Department of Medicine, Division of Nephrology and Hypertension, Georgetown University, Washingt...

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Autores principales:	Lina Nordquist, Fredrik Palm, Bradley T Andresen
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a05b2a93806a4164910264d420380353
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spelling	oai:doaj.org-article:a05b2a93806a4164910264d4203803532021-12-02T05:28:31ZRenal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action1177-54751177-5491https://doaj.org/article/a05b2a93806a4164910264d4203803532008-09-01T00:00:00Zhttp://www.dovepress.com/renal-and-vascular-benefits-of-c-peptide-molecular-mechanisms-of-c-pep-a2294https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Lina Nordquist1, Fredrik Palm1,2, Bradley T Andresen3,41Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden; 2Georgetown University Medical Center, Department of Medicine, Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA; 3University of Missouri, Department of Internal Medicine, Division of Endocrinology, HSC Diabetes Center, Columbia, MO, USA; 4Harry S Truman VA Medical Center, Columbia, MO, USAAbstract: C-peptide has long been thought to be an inert byproduct of insulin production, but it has become apparent, and accepted, that C-peptide has important biological properties. C-peptide displays beneficial effects in many tissues affected by diabetic complications, such as increased peripheral blood flow and protection from renal damage. However, the mechanisms mediating these effects remain unclear. C-peptide interacts with cellular membranes at unidentified sites distinctive of the insulin family of receptors, and signals to multiple targets known to play a role in diabetes and diabetic complications, such as Na+/K+-ATPase and NOS. In general, the physiological and molecular effects of C-peptide resemble insulin, but C-peptide also possesses traits separate from those of insulin. These basic studies have been confirmed in human studies, suggesting that C-peptide may lend itself to clinical applications. However, the molecular and physiological properties of C-peptide are not completely elucidated, and large clinical studies have not begun. In order to further these goals, we critically summarize the current state of knowledge regarding C-peptide&rsquo;s renal and vascular effects and the molecular signaling of C-peptide.Keywords: C-peptide, insulin, diabetes mellitus, nephropathy, vascular, signaling Lina NordquistFredrik PalmBradley T AndresenDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 441-452 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lina Nordquist Fredrik Palm Bradley T Andresen Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
description	Lina Nordquist1, Fredrik Palm1,2, Bradley T Andresen3,41Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden; 2Georgetown University Medical Center, Department of Medicine, Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA; 3University of Missouri, Department of Internal Medicine, Division of Endocrinology, HSC Diabetes Center, Columbia, MO, USA; 4Harry S Truman VA Medical Center, Columbia, MO, USAAbstract: C-peptide has long been thought to be an inert byproduct of insulin production, but it has become apparent, and accepted, that C-peptide has important biological properties. C-peptide displays beneficial effects in many tissues affected by diabetic complications, such as increased peripheral blood flow and protection from renal damage. However, the mechanisms mediating these effects remain unclear. C-peptide interacts with cellular membranes at unidentified sites distinctive of the insulin family of receptors, and signals to multiple targets known to play a role in diabetes and diabetic complications, such as Na+/K+-ATPase and NOS. In general, the physiological and molecular effects of C-peptide resemble insulin, but C-peptide also possesses traits separate from those of insulin. These basic studies have been confirmed in human studies, suggesting that C-peptide may lend itself to clinical applications. However, the molecular and physiological properties of C-peptide are not completely elucidated, and large clinical studies have not begun. In order to further these goals, we critically summarize the current state of knowledge regarding C-peptide&rsquo;s renal and vascular effects and the molecular signaling of C-peptide.Keywords: C-peptide, insulin, diabetes mellitus, nephropathy, vascular, signaling
format	article
author	Lina Nordquist Fredrik Palm Bradley T Andresen
author_facet	Lina Nordquist Fredrik Palm Bradley T Andresen
author_sort	Lina Nordquist
title	Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
title_short	Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
title_full	Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
title_fullStr	Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
title_full_unstemmed	Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
title_sort	renal and vascular benefits of c-peptide: molecular mechanisms of c-peptide action
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a05b2a93806a4164910264d420380353
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Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action

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