Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.

<h4>Background and objective</h4>Previous investigations of glioma risk in women have focused on oral contraceptive (OC), hormone replacement therapy (HRT), and reproductive factors. However, the results of published studies were inconclusive and inconsistent. Thus, a meta-analysis based...

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Autores principales:	Zhen-Yu Qi, Chuan Shao, Xin Zhang, Guo-Zhen Hui, Zhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0604f618a974d18b6f3e3aa19a7317f
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spelling	oai:doaj.org-article:a0604f618a974d18b6f3e3aa19a7317f2021-11-18T07:37:32ZExogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.1932-620310.1371/journal.pone.0068695https://doaj.org/article/a0604f618a974d18b6f3e3aa19a7317f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874728/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objective</h4>Previous investigations of glioma risk in women have focused on oral contraceptive (OC), hormone replacement therapy (HRT), and reproductive factors. However, the results of published studies were inconclusive and inconsistent. Thus, a meta-analysis based on published case-control studies was performed to assess the role of exogenous and endogenous hormones factors in glioma risk.<h4>Methods</h4>The PubMed and EMBASE databases were searched without any restrictions on language or publication year. Reference lists from retrieved articles were also reviewed. We included case-control studies reporting relative risks (RRs) with corresponding 95% confidence intervals (CIs) (or data to calculate them) between oral contraceptive (OC) and hormone replacement therapy (HRT) use, reproductive factors and glioma. Random-effects models were used to calculate the summary risk estimates.<h4>Results</h4>Finally, 11 eligible studies with 4860 cases and 14,740 controls were identified. A lower risk of glioma was observed among women who were ever users of exogenous hormones (OC RR = 0.707, 95% CI = 0.604-0.828; HRT: RR = 0.683, 95% CI = 0.577-0.808) compared with never users. An increased glioma risk was associated with older age at menarche (RR = 1.401, 95% CI = 1.052-1.865). No association was observed for menopause status, parous status, age at menopause, or age at first birth and glioma risk.<h4>Conclusion</h4>The results of our study support the hypothesis female sex hormones play a role in the development of glioma in women. Additional studies are warranted to validate the conclusion from this meta-analysis and clarity the underlying mechanisms.Zhen-Yu QiChuan ShaoXin ZhangGuo-Zhen HuiZhong WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68695 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen-Yu Qi Chuan Shao Xin Zhang Guo-Zhen Hui Zhong Wang Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
description	<h4>Background and objective</h4>Previous investigations of glioma risk in women have focused on oral contraceptive (OC), hormone replacement therapy (HRT), and reproductive factors. However, the results of published studies were inconclusive and inconsistent. Thus, a meta-analysis based on published case-control studies was performed to assess the role of exogenous and endogenous hormones factors in glioma risk.<h4>Methods</h4>The PubMed and EMBASE databases were searched without any restrictions on language or publication year. Reference lists from retrieved articles were also reviewed. We included case-control studies reporting relative risks (RRs) with corresponding 95% confidence intervals (CIs) (or data to calculate them) between oral contraceptive (OC) and hormone replacement therapy (HRT) use, reproductive factors and glioma. Random-effects models were used to calculate the summary risk estimates.<h4>Results</h4>Finally, 11 eligible studies with 4860 cases and 14,740 controls were identified. A lower risk of glioma was observed among women who were ever users of exogenous hormones (OC RR = 0.707, 95% CI = 0.604-0.828; HRT: RR = 0.683, 95% CI = 0.577-0.808) compared with never users. An increased glioma risk was associated with older age at menarche (RR = 1.401, 95% CI = 1.052-1.865). No association was observed for menopause status, parous status, age at menopause, or age at first birth and glioma risk.<h4>Conclusion</h4>The results of our study support the hypothesis female sex hormones play a role in the development of glioma in women. Additional studies are warranted to validate the conclusion from this meta-analysis and clarity the underlying mechanisms.
format	article
author	Zhen-Yu Qi Chuan Shao Xin Zhang Guo-Zhen Hui Zhong Wang
author_facet	Zhen-Yu Qi Chuan Shao Xin Zhang Guo-Zhen Hui Zhong Wang
author_sort	Zhen-Yu Qi
title	Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
title_short	Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
title_full	Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
title_fullStr	Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
title_full_unstemmed	Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
title_sort	exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a0604f618a974d18b6f3e3aa19a7317f
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Exogenous and endogenous hormones in relation to glioma in women: a meta-analysis of 11 case-control studies.

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