Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis

Abstract Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surve...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gabriel Carrasco-Escobar, Dionicia Gamboa, Marcia C. Castro, Shrikant I. Bangdiwala, Hugo Rodriguez, Juan Contreras-Mancilla, Freddy Alava, Niko Speybroeck, Andres G. Lescano, Joseph M. Vinetz, Angel Rosas-Aguirre, Alejandro Llanos-Cuentas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a06360db5b404add9c744db6733396d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a06360db5b404add9c744db6733396d0
record_format	dspace
spelling	oai:doaj.org-article:a06360db5b404add9c744db6733396d02021-12-02T16:06:46ZMicro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis10.1038/s41598-017-07818-02045-2322https://doaj.org/article/a06360db5b404add9c744db6733396d02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07818-0https://doaj.org/toc/2045-2322Abstract Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surveys were conducted between May and July 2015 in four riverine communities in Mazan district. Analysis of 2785 samples of 820 individuals nested within 154 households for Plasmodium parasitaemia was carried out using light microscopy and qPCR. The spatio-temporal distribution of Plasmodium parasitaemia, dominated by P. vivax, was shown to cluster at both household and community levels. Of enrolled individuals, 47% had at least one P. vivax parasitaemia and 10% P. falciparum, by qPCR, both of which were predominantly sub-microscopic and asymptomatic. Spatial analysis detected significant clustering in three communities. Our findings showed that communities at small-to-moderate spatial scales differed in P. vivax parasite prevalence, and multilevel Poisson regression models showed that such differences were influenced by factors such as age, education, and location of households within high-risk clusters, as well as factors linked to a local micro-geographic context, such as travel and occupation. Complex transmission patterns were found to be related to human mobility among communities in the same micro-basin.Gabriel Carrasco-EscobarDionicia GamboaMarcia C. CastroShrikant I. BangdiwalaHugo RodriguezJuan Contreras-MancillaFreddy AlavaNiko SpeybroeckAndres G. LescanoJoseph M. VinetzAngel Rosas-AguirreAlejandro Llanos-CuentasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriel Carrasco-Escobar Dionicia Gamboa Marcia C. Castro Shrikant I. Bangdiwala Hugo Rodriguez Juan Contreras-Mancilla Freddy Alava Niko Speybroeck Andres G. Lescano Joseph M. Vinetz Angel Rosas-Aguirre Alejandro Llanos-Cuentas Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
description	Abstract Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surveys were conducted between May and July 2015 in four riverine communities in Mazan district. Analysis of 2785 samples of 820 individuals nested within 154 households for Plasmodium parasitaemia was carried out using light microscopy and qPCR. The spatio-temporal distribution of Plasmodium parasitaemia, dominated by P. vivax, was shown to cluster at both household and community levels. Of enrolled individuals, 47% had at least one P. vivax parasitaemia and 10% P. falciparum, by qPCR, both of which were predominantly sub-microscopic and asymptomatic. Spatial analysis detected significant clustering in three communities. Our findings showed that communities at small-to-moderate spatial scales differed in P. vivax parasite prevalence, and multilevel Poisson regression models showed that such differences were influenced by factors such as age, education, and location of households within high-risk clusters, as well as factors linked to a local micro-geographic context, such as travel and occupation. Complex transmission patterns were found to be related to human mobility among communities in the same micro-basin.
format	article
author	Gabriel Carrasco-Escobar Dionicia Gamboa Marcia C. Castro Shrikant I. Bangdiwala Hugo Rodriguez Juan Contreras-Mancilla Freddy Alava Niko Speybroeck Andres G. Lescano Joseph M. Vinetz Angel Rosas-Aguirre Alejandro Llanos-Cuentas
author_facet	Gabriel Carrasco-Escobar Dionicia Gamboa Marcia C. Castro Shrikant I. Bangdiwala Hugo Rodriguez Juan Contreras-Mancilla Freddy Alava Niko Speybroeck Andres G. Lescano Joseph M. Vinetz Angel Rosas-Aguirre Alejandro Llanos-Cuentas
author_sort	Gabriel Carrasco-Escobar
title	Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
title_short	Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
title_full	Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
title_fullStr	Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
title_full_unstemmed	Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis
title_sort	micro-epidemiology and spatial heterogeneity of p. vivax parasitaemia in riverine communities of the peruvian amazon: a multilevel analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a06360db5b404add9c744db6733396d0
work_keys_str_mv	AT gabrielcarrascoescobar microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT dioniciagamboa microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT marciaccastro microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT shrikantibangdiwala microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT hugorodriguez microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT juancontrerasmancilla microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT freddyalava microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT nikospeybroeck microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT andresglescano microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT josephmvinetz microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT angelrosasaguirre microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis AT alejandrollanoscuentas microepidemiologyandspatialheterogeneityofpvivaxparasitaemiainriverinecommunitiesoftheperuvianamazonamultilevelanalysis
_version_	1718384859476393984

Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis

Ejemplares similares