Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells

Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life. Clinical studies have shown an increase in airway responsiveness and a concomitant Th2 response in the lungs...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vincent Wellemans, Hassan Ait Benhassou, Eloise Fuselier, Fabienne Bellesort, Sandra Dury, François Lebargy, Valérian Dormoy, Caroline Fichel, Richard Le Naour, Abdelilah S. Gounni, Bouchaib Lamkhioued
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Virology Immunology Cell biology Science Q
Acceso en línea:	https://doaj.org/article/a0639485df8c48b2bfd3f7430ae080ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0639485df8c48b2bfd3f7430ae080ba
record_format	dspace
spelling	oai:doaj.org-article:a0639485df8c48b2bfd3f7430ae080ba2021-12-04T04:35:31ZRole of CCR3 in respiratory syncytial virus infection of airway epithelial cells2589-004210.1016/j.isci.2021.103433https://doaj.org/article/a0639485df8c48b2bfd3f7430ae080ba2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014048https://doaj.org/toc/2589-0042Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life. Clinical studies have shown an increase in airway responsiveness and a concomitant Th2 response in the lungs of RSV-infected patients. These indications suggest that RSV may modulate aspects of the immune response to promote virus replication. Here, we show that CCR3 facilitates RSV infection of airway epithelial cells, an effect that was inhibited by eotaxin-1/CCL11 or upon CCR3 gene silencing. Mechanistically, cellular entry of RSV is mediated by binding of the viral G protein to CCR3 and selective chemotaxis of Th2 cells and eosinophils. In vivo, mice lacking CCR3 display a significant reduction in RSV infection, airway inflammation, and mucus production. Overall, RSV G protein-CCR3 interaction may participate in pulmonary infection and inflammation by enhancing eosinophils' recruitment and less potent antiviral Th2 cells.Vincent WellemansHassan Ait BenhassouEloise FuselierFabienne BellesortSandra DuryFrançois LebargyValérian DormoyCaroline FichelRichard Le NaourAbdelilah S. GounniBouchaib LamkhiouedElsevierarticleVirologyImmunologyCell biologyScienceQENiScience, Vol 24, Iss 12, Pp 103433- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Virology Immunology Cell biology Science Q
spellingShingle	Virology Immunology Cell biology Science Q Vincent Wellemans Hassan Ait Benhassou Eloise Fuselier Fabienne Bellesort Sandra Dury François Lebargy Valérian Dormoy Caroline Fichel Richard Le Naour Abdelilah S. Gounni Bouchaib Lamkhioued Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
description	Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life. Clinical studies have shown an increase in airway responsiveness and a concomitant Th2 response in the lungs of RSV-infected patients. These indications suggest that RSV may modulate aspects of the immune response to promote virus replication. Here, we show that CCR3 facilitates RSV infection of airway epithelial cells, an effect that was inhibited by eotaxin-1/CCL11 or upon CCR3 gene silencing. Mechanistically, cellular entry of RSV is mediated by binding of the viral G protein to CCR3 and selective chemotaxis of Th2 cells and eosinophils. In vivo, mice lacking CCR3 display a significant reduction in RSV infection, airway inflammation, and mucus production. Overall, RSV G protein-CCR3 interaction may participate in pulmonary infection and inflammation by enhancing eosinophils' recruitment and less potent antiviral Th2 cells.
format	article
author	Vincent Wellemans Hassan Ait Benhassou Eloise Fuselier Fabienne Bellesort Sandra Dury François Lebargy Valérian Dormoy Caroline Fichel Richard Le Naour Abdelilah S. Gounni Bouchaib Lamkhioued
author_facet	Vincent Wellemans Hassan Ait Benhassou Eloise Fuselier Fabienne Bellesort Sandra Dury François Lebargy Valérian Dormoy Caroline Fichel Richard Le Naour Abdelilah S. Gounni Bouchaib Lamkhioued
author_sort	Vincent Wellemans
title	Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
title_short	Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
title_full	Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
title_fullStr	Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
title_full_unstemmed	Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
title_sort	role of ccr3 in respiratory syncytial virus infection of airway epithelial cells
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a0639485df8c48b2bfd3f7430ae080ba
work_keys_str_mv	AT vincentwellemans roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT hassanaitbenhassou roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT eloisefuselier roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT fabiennebellesort roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT sandradury roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT francoislebargy roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT valeriandormoy roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT carolinefichel roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT richardlenaour roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT abdelilahsgounni roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells AT bouchaiblamkhioued roleofccr3inrespiratorysyncytialvirusinfectionofairwayepithelialcells
_version_	1718372931537469440

Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells

Ejemplares similares