Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pa...
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Public Library of Science (PLoS)
2014
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oai:doaj.org-article:a06625b69c34481face921efb5d48b512021-11-11T08:21:09ZEctosomes: a new mechanism for non-exosomal secretion of tau protein.1932-620310.1371/journal.pone.0100760https://doaj.org/article/a06625b69c34481face921efb5d48b512014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24971751/?tool=EBIhttps://doaj.org/toc/1932-6203Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.Simon DujardinSéverine BégardRaphaëlle CaillierezCédrick LachaudLucie DelattreSébastien CarrierAnne LoyensMarie-Christine GalasLuc BoussetRonald MelkiGwennaëlle AuréganPhilippe HantrayeEmmanuel BrouilletLuc BuéeMorvane ColinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100760 (2014) |
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DOAJ |
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| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Simon Dujardin Séverine Bégard Raphaëlle Caillierez Cédrick Lachaud Lucie Delattre Sébastien Carrier Anne Loyens Marie-Christine Galas Luc Bousset Ronald Melki Gwennaëlle Aurégan Philippe Hantraye Emmanuel Brouillet Luc Buée Morvane Colin Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| description |
Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated. |
| format |
article |
| author |
Simon Dujardin Séverine Bégard Raphaëlle Caillierez Cédrick Lachaud Lucie Delattre Sébastien Carrier Anne Loyens Marie-Christine Galas Luc Bousset Ronald Melki Gwennaëlle Aurégan Philippe Hantraye Emmanuel Brouillet Luc Buée Morvane Colin |
| author_facet |
Simon Dujardin Séverine Bégard Raphaëlle Caillierez Cédrick Lachaud Lucie Delattre Sébastien Carrier Anne Loyens Marie-Christine Galas Luc Bousset Ronald Melki Gwennaëlle Aurégan Philippe Hantraye Emmanuel Brouillet Luc Buée Morvane Colin |
| author_sort |
Simon Dujardin |
| title |
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| title_short |
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| title_full |
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| title_fullStr |
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| title_full_unstemmed |
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| title_sort |
ectosomes: a new mechanism for non-exosomal secretion of tau protein. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/a06625b69c34481face921efb5d48b51 |
| work_keys_str_mv |
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| _version_ |
1718439335562313728 |