Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus

Abstract Although the cannabinoid receptor 2 (CB2R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB2R on hippocampal principal neurons. Activation of CB2R produced a long-lasting membrane potential hyperpolarization, altered the i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joanna Agnieszka Komorowska-Müller, Kishore Aravind Ravichandran, Andreas Zimmer, Britta Schürmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a06d0c91de694227bf510861315c0022
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a06d0c91de694227bf510861315c0022
record_format	dspace
spelling	oai:doaj.org-article:a06d0c91de694227bf510861315c00222021-12-02T17:08:36ZCannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus10.1038/s41598-021-96285-92045-2322https://doaj.org/article/a06d0c91de694227bf510861315c00222021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96285-9https://doaj.org/toc/2045-2322Abstract Although the cannabinoid receptor 2 (CB2R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB2R on hippocampal principal neurons. Activation of CB2R produced a long-lasting membrane potential hyperpolarization, altered the input/output function of CA2/3 principal neurons and produced alterations in gamma oscillations. However, other cellular, molecular and behavioral consequences of hippocampal CB2R signaling have not been studied in detail. Here we demonstrate that the deletion of CB2 leads to a highly significant increase in hippocampal synapsin-I expression levels and particle density, as well as increased vesicular GABA transporter (vGAT) levels. This phenotype was restricted to females and not observed in males. Furthermore, we demonstrate an impairment of social memory in CB2 deficient mice. Our results thus demonstrate that the lack of CB2R leads to changes in the hippocampal synaptic landscape and reveals an important sex-specific difference in endocannabinoid signaling. This study supports a significant role of the CB2R in modulation of different types of memory despite its low expression levels in the brain and provides more insight into a sex-specific role of CB2R in synaptic architecture.Joanna Agnieszka Komorowska-MüllerKishore Aravind RavichandranAndreas ZimmerBritta SchürmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Agnieszka Komorowska-Müller Kishore Aravind Ravichandran Andreas Zimmer Britta Schürmann Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
description	Abstract Although the cannabinoid receptor 2 (CB2R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB2R on hippocampal principal neurons. Activation of CB2R produced a long-lasting membrane potential hyperpolarization, altered the input/output function of CA2/3 principal neurons and produced alterations in gamma oscillations. However, other cellular, molecular and behavioral consequences of hippocampal CB2R signaling have not been studied in detail. Here we demonstrate that the deletion of CB2 leads to a highly significant increase in hippocampal synapsin-I expression levels and particle density, as well as increased vesicular GABA transporter (vGAT) levels. This phenotype was restricted to females and not observed in males. Furthermore, we demonstrate an impairment of social memory in CB2 deficient mice. Our results thus demonstrate that the lack of CB2R leads to changes in the hippocampal synaptic landscape and reveals an important sex-specific difference in endocannabinoid signaling. This study supports a significant role of the CB2R in modulation of different types of memory despite its low expression levels in the brain and provides more insight into a sex-specific role of CB2R in synaptic architecture.
format	article
author	Joanna Agnieszka Komorowska-Müller Kishore Aravind Ravichandran Andreas Zimmer Britta Schürmann
author_facet	Joanna Agnieszka Komorowska-Müller Kishore Aravind Ravichandran Andreas Zimmer Britta Schürmann
author_sort	Joanna Agnieszka Komorowska-Müller
title	Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
title_short	Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
title_full	Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
title_fullStr	Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
title_full_unstemmed	Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
title_sort	cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a06d0c91de694227bf510861315c0022
work_keys_str_mv	AT joannaagnieszkakomorowskamuller cannabinoidreceptor2deletioninfluencessocialmemoryandsynapticarchitectureinthehippocampus AT kishorearavindravichandran cannabinoidreceptor2deletioninfluencessocialmemoryandsynapticarchitectureinthehippocampus AT andreaszimmer cannabinoidreceptor2deletioninfluencessocialmemoryandsynapticarchitectureinthehippocampus AT brittaschurmann cannabinoidreceptor2deletioninfluencessocialmemoryandsynapticarchitectureinthehippocampus
_version_	1718381571466067968

Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus

Ejemplares similares