Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes

Background: Increased arterial stiffness is associated with diastolic dysfunction in adults. Data in youth are lacking, so we examined the impact of arterial stiffness on diastolic function in youth.Methods: We obtained diastolic function and augmentation index, pulse wave velocity, brachial artery...

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Autores principales:	Nicolas L. Madsen, Jessica E. Haley, Ryan A. Moore, Philip R. Khoury, Elaine M. Urbina
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	arterial stiffness diastolic dysfunction pediatrics obesity T2DM Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/a06dfd120cf643418181dc66997bbabf
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spelling	oai:doaj.org-article:a06dfd120cf643418181dc66997bbabf2021-12-01T13:12:20ZIncreased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes2296-236010.3389/fped.2021.781496https://doaj.org/article/a06dfd120cf643418181dc66997bbabf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.781496/fullhttps://doaj.org/toc/2296-2360Background: Increased arterial stiffness is associated with diastolic dysfunction in adults. Data in youth are lacking, so we examined the impact of arterial stiffness on diastolic function in youth.Methods: We obtained diastolic function and augmentation index, pulse wave velocity, brachial artery distensibility, and carotid stiffness on 612 youth [10–24 years, 65% female, 38% normal weight, 36% obese, and 26% with type 2 diabetes mellitus (T2DM)]. Participants were classified as compliant (C) vs. stiff (S) arteries based on seven arterial stiffness parameters [Global Stiffness Index (GSI), S = GSI > 4). Mean differences in covariates were evaluated by Student's t-tests. A stepwise regression analysis was performed to determine if GSI was an independent predictor of diastolic function.Results: Lower diastolic function and more adverse cardiovascular disease (CVD) risk factors were present in the S group (n = 67) than the C group (n = 545) (p < 0.001). Covariates that were associated with diastolic dysfunction were higher GSI, male sex, higher body mass index (BMI), and systolic blood pressure (SBP) z-score (R2 = 0.18 to 0.25; p ≤ 0.05).Conclusion: Adverse diastolic function is seen in youth with increased arterial stiffness independent of CVD risk factors. Interventions to improve arterial stiffness prior to clinical onset of diastolic dysfunction are needed to prevent development of heart failure.Nicolas L. MadsenJessica E. HaleyRyan A. MoorePhilip R. KhouryElaine M. UrbinaFrontiers Media S.A.articlearterial stiffnessdiastolic dysfunctionpediatricsobesityT2DMPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial stiffness diastolic dysfunction pediatrics obesity T2DM Pediatrics RJ1-570
spellingShingle	arterial stiffness diastolic dysfunction pediatrics obesity T2DM Pediatrics RJ1-570 Nicolas L. Madsen Jessica E. Haley Ryan A. Moore Philip R. Khoury Elaine M. Urbina Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
description	Background: Increased arterial stiffness is associated with diastolic dysfunction in adults. Data in youth are lacking, so we examined the impact of arterial stiffness on diastolic function in youth.Methods: We obtained diastolic function and augmentation index, pulse wave velocity, brachial artery distensibility, and carotid stiffness on 612 youth [10–24 years, 65% female, 38% normal weight, 36% obese, and 26% with type 2 diabetes mellitus (T2DM)]. Participants were classified as compliant (C) vs. stiff (S) arteries based on seven arterial stiffness parameters [Global Stiffness Index (GSI), S = GSI > 4). Mean differences in covariates were evaluated by Student's t-tests. A stepwise regression analysis was performed to determine if GSI was an independent predictor of diastolic function.Results: Lower diastolic function and more adverse cardiovascular disease (CVD) risk factors were present in the S group (n = 67) than the C group (n = 545) (p < 0.001). Covariates that were associated with diastolic dysfunction were higher GSI, male sex, higher body mass index (BMI), and systolic blood pressure (SBP) z-score (R2 = 0.18 to 0.25; p ≤ 0.05).Conclusion: Adverse diastolic function is seen in youth with increased arterial stiffness independent of CVD risk factors. Interventions to improve arterial stiffness prior to clinical onset of diastolic dysfunction are needed to prevent development of heart failure.
format	article
author	Nicolas L. Madsen Jessica E. Haley Ryan A. Moore Philip R. Khoury Elaine M. Urbina
author_facet	Nicolas L. Madsen Jessica E. Haley Ryan A. Moore Philip R. Khoury Elaine M. Urbina
author_sort	Nicolas L. Madsen
title	Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
title_short	Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
title_full	Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
title_fullStr	Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
title_full_unstemmed	Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes
title_sort	increased arterial stiffness is associated with reduced diastolic function in youth with obesity and type 2 diabetes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a06dfd120cf643418181dc66997bbabf
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Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes

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